The authors compared the in vitro antibacterial activity of aqueous and alcoholic extracts of leaves of Cassia alata, Lantana camara and Mitracarpus scaber on Dermatophilus congolensis – a Gram-positive bacteria that causes bovine dermatophilosis – with that of oxytetracyclin and procain benzylpenicillin. Crude alcoholic extracts of C. alata, L. camara and M. scaber were more effective on D. congolensis than aqueous extracts. On a strain isolated from infected animals, the inhibiting zones diameters were 14–20 mm and 20–24 mm for aqueous and alcoholic extracts at 500 mg/ml, respectively. Both M. scaber extracts showed a higher antibacterial activity on D. congolensis than those of C. alata and L. camara. In vitro antibacterial activity of crude alcoholic extracts of M. scaber at 500 mg/ml on D. congolensis was equivalent to that of procain benzylpenicillin at 800 mg/ml, and about 10–15 times lower than that of oxytetracyclin.