publication . Article . Other literature type . 2016

1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America

Thomas D. Watts; Richard A. McKay; Walid Heneine; Beryl A. Koblin; Timothy C. Granade; Harold W. Jaffe; Dirk E. Teuwen; Marc A. Suchard; Michael Worobey; Philippe Lemey;
Open Access English
  • Published: 26 Oct 2016
  • Publisher: Nature Publishing Group
  • Country: United Kingdom
This is the author accepted manuscript. The final version is available from Nature Publishing Group via The emergence of HIV-1 group M subtype B in North American men who have sex with men was a key turning point in the HIV/AIDS pandemic. Phylogenetic studies have suggested cryptic subtype B circulation in the United States (US) throughout the 1970s$^{1,2}$ and an even older presence in the Caribbean$^{2}$. However, these temporal and geographical inferences, based upon partial HIV-1 genomes that postdate the recognition of AIDS in 1981, remain contentious$^{3,4}$ and the earliest movements of the virus within the US are unkno...
free text keywords: Article, Multidisciplinary, Virus, Zoology, Genetic diversity, Phylogenetics, Coalescent theory, Biology, Evolutionary biology, Phylogenetic tree, Men who have sex with men, Genome, Acquired immunodeficiency syndrome (AIDS), medicine.disease, medicine
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Other literature type . 2016
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Article . 2016
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