publication . Article . Other literature type . 2001

Transmission/Disequilibrium Test Meets Measured Haplotype Analysis: Family-Based Association Analysis Guided by Evolution of Haplotypes

H Seltman; K Roeder; B Devlin;
Open Access
  • Published: 01 May 2001 Journal: The American Journal of Human Genetics, volume 68, issue 5, pages 1,250-1,263 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Family data teamed with the transmission/disequilibrium test (TDT), which simultaneously evaluates linkage and association, is a powerful means of detecting disease-liability alleles. To increase the information provided by the test, various researchers have proposed TDT-based methods for haplotype transmission. Haplotypes indeed produce more-definitive transmissions than do the alleles comprising them, and this tends to increase power. However, the larger number of haplotypes, relative to alleles at individual loci, tends to decrease power, because of the additional degrees of freedom required for the test. An optimal strategy would focus the test on particular...
Subjects
Medical Subject Headings: stomatognathic diseases
free text keywords: Genetics(clinical), Genetics, Articles, Linkage disequilibrium, Transmission disequilibrium test, Statistical hypothesis testing, Genetic association, Disequilibrium, medicine.symptom, medicine, Biology, Phylogenetic tree, Haplotype, Locus (genetics)
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