publication . Article . Other literature type . 2013

Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders.

Eider M. Arenaza-Urquijo; Brigitte Landeau; Renaud La Joie; Katell Mevel; Florence Mézenge; Audrey Perrotin; Béatrice Desgranges; David Bartrés-Faz; Francis Eustache; Gaël Chételat;
Open Access English
  • Published: 21 Jun 2013
  • Publisher: HAL CCSD
Abstract
International audience; More educated elders are less susceptible to age-related or pathological cognitive changes. We aimed at providing a comprehensive contribution to the neural mechanism underlying this effect thanks to a multimodal approach. Thirty-six healthy elders were selected based on neuropsychological assessments and cerebral amyloid imaging, i.e. as presenting normal cognition and a negative florbetapir-PET scan. All subjects underwent structural MRI, FDG-PET and resting-state functional MRI scans. We assessed the relationships between years of education and i) gray matter volume, ii) gray matter metabolism and iii) functional connectivity in the br...
Subjects
free text keywords: education, cognitive aging, brain reserve, cognitive reserve, functional connectivity, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Cognitive Neuroscience, Neurology, Anterior cingulate cortex, medicine.anatomical_structure, medicine, Superior temporal gyrus, Emotional lateralization, Developmental psychology, Posterior cingulate, Neuroscience, Frontal lobe, Cognitive psychology, Hippocampus, Psychology, Angular gyrus, Insula
23 references, page 1 of 2

Albert, M.S., Jones, K., Savage, C.R., Berkman, L., Seeman, T., Blazer, D., Rowe, J.W., 1995. Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol Aging 10, 578-589.

Alvarado, B.E., Zunzunegui, M.-V., Del Ser, T., Béland, F., 2002. Cognitive decline is related to education and occupation in a Spanish elderly cohort. Aging Clin Exp Res 14, 132-142.

Anstey, K.J., Hofer, S.M., Luszcz, M.A., 2003. A latent growth curve analysis of latelife sensory and cognitive function over 8 years: evidence for specific and common factors underlying change. Psychol Aging 18, 714-726. [OpenAIRE]

Arenaza-Urquijo, E.M., Bosch, B., Sala-Llonch, R., Solé-Padullés, C., Junqué, C., Fernández-Espejo D., Bargalló, N., Rami L., Molinuevo, J.L., Bartrés-Faz, D., 2011. Specific anatomic associations between white matter integrity and cognitive reserve in normal and cognitively impaired elders. Am J Geriatr Psychiatry 19: 33-42. [OpenAIRE]

Arenaza-Urquijo, E.M., Molinuevo, J.-L., Sala-Llonch, R., Solé-Padullés, C., Balasa, M., Bosch, B., Olives, J., Antonell, A., Lladó, A., Sánchez-Valle, R., Rami, L., Bartrés-Faz, D., 2013. Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels. J. Alzheimers Dis.

Bartrés-Faz, D., Arenaza-Urquijo, E.M., 2011. Structural and functional imaging correlates of cognitive and brain reserve hypotheses in healthy and pathological aging. Brain Topogr 24, 340-357. [OpenAIRE]

Bartrés-Faz, D., Solé-Padullés, C., Junqué, C., Rami, L., Bosch, B., Bargalló, N., Falcón, C., Sánchez-Valle, R., Molinuevo, J.L., 2009. Interactions of cognitive Viader, F., Eustache, F., Baron, J.-C., 2008. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer‟s disease. Brain 131, 60-71.

Chételat, G., Villemagne, V.L., Pike, K.E., Baron, J.-C., Bourgeat, P., Jones, G., Faux, N.G., Ellis, K.A., Salvado, O., Szoeke, C., Martins, R.N., Ames, D., Masters, C.L., Rowe, C.C., 2010. Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain 133, 3349-3358. [OpenAIRE]

Christensen, H., Batterham, P.J., Mackinnon, A.J., Anstey, K.J., Wen, W., Sachdev, P.S., 2009. Education, atrophy, and cognitive change in an epidemiological sample in early old age. Am J Geriatr Psychiatry 17, 218-226. [OpenAIRE]

Christensen, H., Korten, A.E., Jorm, A.F., Henderson, A.S., Jacomb, P.A., Rodgers, B., Mackinnon, A.J., 1997. Education and decline in cognitive performance: compensatory but not protective. Int J Geriatr Psychiatry 12, 323-330.

Draganski, B., Gaser, C., Kempermann, G., Kuhn, H.G., Winkler, J., Büchel, C., May, A., 2006. Temporal and spatial dynamics of brain structure changes during extensive learning. J. Neurosci. 26, 6314-6317. [OpenAIRE]

Erten-Lyons, D., Woltjer, R.L., Dodge, H., Nixon, R., Vorobik, R., Calvert, J.F., Leahy, M., Montine, T., Kaye, J., 2009. Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurology 72, 354-360. [OpenAIRE]

Evans, D.A., Beckett, L.A., Albert, M.S., Hebert, L.E., Scherr, P.A., Funkenstein, H.H., Taylor, J.O., 1993. Level of education and change in cognitive function in a community population of older persons. Ann Epidemiol 3, 71-77.

Ewers, M., Insel, P.S., Stern, Y., Weiner, M.W., 2013. Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease. Neurology 80, 1194-1201. [OpenAIRE]

Farmer, M.E., Kittner, S.J., Rae, D.S., Bartko, J.J., Regier, D.A., 1995. Education and 935.

23 references, page 1 of 2
Abstract
International audience; More educated elders are less susceptible to age-related or pathological cognitive changes. We aimed at providing a comprehensive contribution to the neural mechanism underlying this effect thanks to a multimodal approach. Thirty-six healthy elders were selected based on neuropsychological assessments and cerebral amyloid imaging, i.e. as presenting normal cognition and a negative florbetapir-PET scan. All subjects underwent structural MRI, FDG-PET and resting-state functional MRI scans. We assessed the relationships between years of education and i) gray matter volume, ii) gray matter metabolism and iii) functional connectivity in the br...
Subjects
free text keywords: education, cognitive aging, brain reserve, cognitive reserve, functional connectivity, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Cognitive Neuroscience, Neurology, Anterior cingulate cortex, medicine.anatomical_structure, medicine, Superior temporal gyrus, Emotional lateralization, Developmental psychology, Posterior cingulate, Neuroscience, Frontal lobe, Cognitive psychology, Hippocampus, Psychology, Angular gyrus, Insula
23 references, page 1 of 2

Albert, M.S., Jones, K., Savage, C.R., Berkman, L., Seeman, T., Blazer, D., Rowe, J.W., 1995. Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol Aging 10, 578-589.

Alvarado, B.E., Zunzunegui, M.-V., Del Ser, T., Béland, F., 2002. Cognitive decline is related to education and occupation in a Spanish elderly cohort. Aging Clin Exp Res 14, 132-142.

Anstey, K.J., Hofer, S.M., Luszcz, M.A., 2003. A latent growth curve analysis of latelife sensory and cognitive function over 8 years: evidence for specific and common factors underlying change. Psychol Aging 18, 714-726. [OpenAIRE]

Arenaza-Urquijo, E.M., Bosch, B., Sala-Llonch, R., Solé-Padullés, C., Junqué, C., Fernández-Espejo D., Bargalló, N., Rami L., Molinuevo, J.L., Bartrés-Faz, D., 2011. Specific anatomic associations between white matter integrity and cognitive reserve in normal and cognitively impaired elders. Am J Geriatr Psychiatry 19: 33-42. [OpenAIRE]

Arenaza-Urquijo, E.M., Molinuevo, J.-L., Sala-Llonch, R., Solé-Padullés, C., Balasa, M., Bosch, B., Olives, J., Antonell, A., Lladó, A., Sánchez-Valle, R., Rami, L., Bartrés-Faz, D., 2013. Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels. J. Alzheimers Dis.

Bartrés-Faz, D., Arenaza-Urquijo, E.M., 2011. Structural and functional imaging correlates of cognitive and brain reserve hypotheses in healthy and pathological aging. Brain Topogr 24, 340-357. [OpenAIRE]

Bartrés-Faz, D., Solé-Padullés, C., Junqué, C., Rami, L., Bosch, B., Bargalló, N., Falcón, C., Sánchez-Valle, R., Molinuevo, J.L., 2009. Interactions of cognitive Viader, F., Eustache, F., Baron, J.-C., 2008. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer‟s disease. Brain 131, 60-71.

Chételat, G., Villemagne, V.L., Pike, K.E., Baron, J.-C., Bourgeat, P., Jones, G., Faux, N.G., Ellis, K.A., Salvado, O., Szoeke, C., Martins, R.N., Ames, D., Masters, C.L., Rowe, C.C., 2010. Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain 133, 3349-3358. [OpenAIRE]

Christensen, H., Batterham, P.J., Mackinnon, A.J., Anstey, K.J., Wen, W., Sachdev, P.S., 2009. Education, atrophy, and cognitive change in an epidemiological sample in early old age. Am J Geriatr Psychiatry 17, 218-226. [OpenAIRE]

Christensen, H., Korten, A.E., Jorm, A.F., Henderson, A.S., Jacomb, P.A., Rodgers, B., Mackinnon, A.J., 1997. Education and decline in cognitive performance: compensatory but not protective. Int J Geriatr Psychiatry 12, 323-330.

Draganski, B., Gaser, C., Kempermann, G., Kuhn, H.G., Winkler, J., Büchel, C., May, A., 2006. Temporal and spatial dynamics of brain structure changes during extensive learning. J. Neurosci. 26, 6314-6317. [OpenAIRE]

Erten-Lyons, D., Woltjer, R.L., Dodge, H., Nixon, R., Vorobik, R., Calvert, J.F., Leahy, M., Montine, T., Kaye, J., 2009. Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurology 72, 354-360. [OpenAIRE]

Evans, D.A., Beckett, L.A., Albert, M.S., Hebert, L.E., Scherr, P.A., Funkenstein, H.H., Taylor, J.O., 1993. Level of education and change in cognitive function in a community population of older persons. Ann Epidemiol 3, 71-77.

Ewers, M., Insel, P.S., Stern, Y., Weiner, M.W., 2013. Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease. Neurology 80, 1194-1201. [OpenAIRE]

Farmer, M.E., Kittner, S.J., Rae, D.S., Bartko, J.J., Regier, D.A., 1995. Education and 935.

23 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2013

Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders.

Eider M. Arenaza-Urquijo; Brigitte Landeau; Renaud La Joie; Katell Mevel; Florence Mézenge; Audrey Perrotin; Béatrice Desgranges; David Bartrés-Faz; Francis Eustache; Gaël Chételat;