publication . Article . Other literature type . 1998

A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.

Richard S. Spielman; Warren J. Ewens;
Open Access
  • Published: 01 Feb 1998 Journal: The American Journal of Human Genetics, volume 62, issue 2, pages 450-458 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Summary Linkage analysis with genetic markers has been successful in the localization of genes for many monogenic human diseases. In studies of complex diseases, however, tests that rely on linkage disequilibrium (the simultaneous presence of linkage and association) are often more powerful than those that rely on linkage alone. This advantage is illustrated by the transmission/disequilibrium test (TDT). The TDT requires data (marker genotypes) for affected individuals and their parents; for some diseases, however, data from parents may be difficult or impossible to obtain. In this article, we describe a method, called the "sib TDT" (or "S-TDT"), that overcomes ...
Subjects
Medical Subject Headings: stomatognathic diseasesendocrine system
free text keywords: Genetics(clinical), Genetics, Research Article, Transmission/disequilibrium test, Linkage disequilibrium, Sibship test, Diseases of late onset, Disease association
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