publication . Other literature type . Article . 2007

Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.

d'Anglemont de Tassigny, X.; Fagg, L.A.; Dixon, J.P.C.; Day, K.; Leitch, H.G.; Hendrick, A.G.; Zahn, D.; Franceschini, Isabelle; Caraty, Alain; Carlton, M.B.L.; ...
Open Access English
  • Published: 11 Jun 2007
  • Publisher: National Academy of Sciences
  • Country: France
Abstract
The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are encoded by the Kiss1 gene, and administration of exogenous kisspeptins stimulates hypothalamic gonadotropin-releasing hormone (GnRH) release in several species, including humans. To establish that kisspeptins are the authentic agonists of GPR54 in vivo and to determine whether these ligands have additional physiological functions we have generated mice with a targeted disruption of the Kiss1 gene. Kiss1-null mice are viable and healthy with no apparent abnormalities but fail to undergo sexual ...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonistsendocrine system
free text keywords: Biological Sciences, SOURIS KNOCKOUT, GENE KISS-1, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Endocrinology, medicine.medical_specialty, medicine, Hypogonadotropic hypogonadism, medicine.disease, Testosterone, Luteinizing hormone secretion, Sex steroid, Kisspeptins, Gonadotropin-releasing hormone, Luteinizing hormone, Biology, Internal medicine, Kisspeptin
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publication . Other literature type . Article . 2007

Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.

d'Anglemont de Tassigny, X.; Fagg, L.A.; Dixon, J.P.C.; Day, K.; Leitch, H.G.; Hendrick, A.G.; Zahn, D.; Franceschini, Isabelle; Caraty, Alain; Carlton, M.B.L.; ...