publication . Other literature type . Article . 2008

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

McCarthy, MI; Abecasis, GR; Cardon, LR; Goldstein, DB; Little, J; Ioannidis, JP; Hirschhorn, JN;
  • Published: 01 May 2008
  • Publisher: Springer Science and Business Media LLC
  • Country: United Kingdom
The past year has witnessed substantial advances in understanding the genetic basis of many common phenotypes of biomedical importance. These advances have been the result of systematic, well-powered, genome-wide surveys exploring the relationships between common sequence variation and disease predisposition. This approach has revealed over 50 disease-susceptibility loci and has provided insights into the allelic architecture of multifactorial traits. At the same time, much has been learned about the successful prosecution of association studies on such a scale. This Review highlights the knowledge gained, defines areas of emerging consensus, and describes the c...
free text keywords: Genetics(clinical), Genetics, Molecular Biology, Allele, Quantitative trait locus, Genetic association, Genome-wide association study, Genetic variation, Disease, Sequence variation, Locus (genetics), Biology
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