publication . Other literature type . Article . 2008

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

McCarthy, MI; Abecasis, GR; Cardon, LR; Goldstein, DB; Little, J; Ioannidis, JP; Hirschhorn, JN;
  • Published: 01 May 2008
  • Publisher: Springer Science and Business Media LLC
  • Country: United Kingdom
Abstract
The past year has witnessed substantial advances in understanding the genetic basis of many common phenotypes of biomedical importance. These advances have been the result of systematic, well-powered, genome-wide surveys exploring the relationships between common sequence variation and disease predisposition. This approach has revealed over 50 disease-susceptibility loci and has provided insights into the allelic architecture of multifactorial traits. At the same time, much has been learned about the successful prosecution of association studies on such a scale. This Review highlights the knowledge gained, defines areas of emerging consensus, and describes the c...
Subjects
free text keywords: Genetics(clinical), Genetics, Molecular Biology, Allele, Quantitative trait locus, Genetic association, Genome-wide association study, Genetic variation, Disease, Sequence variation, Locus (genetics), Biology
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