publication . Article . 2009

CSF biomarker levels in early and late onset Alzheimer's disease

Femke H. Bouwman; Niki S.M. Schoonenboom; Nicolaas A. Verwey; Evert J. van Elk; Astrid Kok; Marinus A. Blankenstein; Philip Scheltens; Wiesje M. van der Flier;
  • Published: 01 Jan 2009
  • Publisher: Elsevier BV
  • Country: Netherlands
Abstract Objective To compare CSF levels of beta-amyloid 1–42 (Aβ1–42), total tau (tau) and tau phosphorylated at threonine 181 (ptau-181) between AD patients and controls according to age. Methods 248 AD patients (48% men) and 127 controls (51% men, 22 volunteers and 105 subjective complainers) underwent lumbar puncture. Both patients and controls were divided into a young ( Results All three biomarkers showed main effects of diagnosis (p  Conclusion We found that the older control group had lower Aβ1–42 and higher (p)tau compared to the younger control group. This suggests that older individuals may have AD pathology, even in the absence of objective cognitive...
free text keywords: Developmental Biology, Ageing, General Neuroscience, Geriatrics and Gerontology, Clinical Neurology, Pathology, medicine.medical_specialty, medicine, Late onset, Cerebrospinal fluid, Gastroenterology, Central nervous system disease, medicine.disease, Endocrinology, Alzheimer's disease, Biomarker (medicine), Diabetes mellitus, Internal medicine, Age of onset, business.industry, business, Lumbar puncture, medicine.diagnostic_test
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