publication . Article . Other literature type . 2012

Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation.

Tassilo Volz;
Restricted
  • Published: 30 Jan 2012 Journal: Hepatology, volume 55, pages 685-694 (issn: 0270-9139, Copyright policy)
  • Publisher: Wiley
Abstract
No specific drugs are currently available against hepatitis delta virus (HDV), a defective virus leading to the most severe form of chronic viral hepatitis in man. The lack of convenient HDV infection models has hampered the development of effective therapeutics. In this study, nai¨ve and hepatitis B virus (HBV) chronically infected humanized uPA/SCID mice were employed to establish a small animal model of HBV/HDV coinfection and superinfection. For preclinical antiviral drug evaluation, the GMP version of the myristoylated preS-peptide (Myrcludex-B), a lipopeptide derived from the pre-S1 domain of the HBV envelope, was applied to prevent de novo HBV/HDV coinfec...
Subjects
Medical Subject Headings: virus diseasesvirusesbiochemical phenomena, metabolism, and nutritiondigestive system diseases
free text keywords: Hepatology
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