publication . Article . 2012

Obesity and endocrine dysfunction programmed by maternal smoking in pregnancy and lactation.

Patricia Lisboa; Egberto Moura;
Open Access English
  • Published: 01 Nov 2012 Journal: Frontiers in Physiology (issn: 1664-042X, Copyright policy)
  • Publisher: Frontiers Media S.A.
Obesity is a global epidemic, and maternal smoking has been shown to be associated with the development of childhood obesity. Overall, approximately 40% of children worldwide are exposed to tobacco smoke at home. It is well known that environmental changes within a critical window of development, such as gestation or lactation, can initiate permanent alterations in metabolism that lead to diseases in adulthood, a phenomenon called programming. It is known that programming is based on epigenetic alterations (changes in DNA methylation, histone acetylation or small interfering RNA expression) that change the expression pattern of several genes. However, little is ...
free text keywords: Hormones, Lactation, Nicotine, Obesity, Tobacco, programming, Physiology, QP1-981, Review Article, gestation, Physiology (medical)
107 references, page 1 of 8

Ahima R. S. Prabakaran D. Mantzoros C. Qu D. Lowell B. Maratos-Flier E. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252.10.1038/382250a0 8717038 [OpenAIRE] [PubMed] [DOI]

Barker D. J. (2003). The developmental origins of adult disease. Eur. J. Epidemiol. 18, 733–736.10.1023/A:1025388901248 12974544 [OpenAIRE] [PubMed] [DOI]

Bruin J. E. Kellenberger L. D. Gerstein H. C. Morrison K. Holloway A. C. (2007). Fetal and neonatal nicotine exposure and postnatal glucose: identifying critical windows of exposure. J. Endocrinol. 194, 171–178.10.1677/JOE-07-0050 17592031 [PubMed] [DOI]

Centers for Disease Control and Prevention (CDC). (2012). Smoking and Tobacco Use. Available at: [accessed May 8, 2012]

Chanoine J. P. Toppet V. Bourdoux P. Spehl M. Delange F. (1991). Smoking during pregnancy: a significant cause of neonatal thyroid enlargement. BJOG 98, 65–68.10.1111/j.1471-0528.1991.tb10313.x [OpenAIRE] [DOI]

Chen W. J. Kelly R. B. (2005). Effect of prenatal or perinatal nicotine exposure o neonatal thyroid status and offspring growth in rats. Life Sci. 76, 1249–1258.10.1016/j.lfs.2004.08.014 15642595 [OpenAIRE] [PubMed] [DOI]

Chiolero A. Faeh D. Paccaud F. Cornuz J. (2008). Consequences of smoking for body weight, body distribution and insulin resistance. Am. J. Clin. Nutr. 87, 801–809.18400700 [OpenAIRE] [PubMed]

Christensen S. B. Ericsson U. B. Janzon L. Tibblin S. Melander A. (1984). Influence of cigarette smoking on goiter fo rmation, thyroglobulin, and thyroid hormone levels in women. J. Clin. Endocrinol. Metab. 58, 615–618.10.1210/jcem-58-4-615 6699129 [OpenAIRE] [PubMed] [DOI]

Clancy B. Finlay B. L. Darlington R. B. Anand K. J. (2007). Extrapolating brain development from experimental species to humans. Neurotoxicology 28, 931–937.10.1016/j.neuro.2007.01.014 17368774 [OpenAIRE] [PubMed] [DOI]

Dahlström A. Ebersjö C. Lundell B. (2004). Nicotine exposure in breastfed infants. Acta Paediatr. 93, 810–816.10.1111/j.1651-2227.2004.tb03023.x 15244232 [OpenAIRE] [PubMed] [DOI]

Dai Z. Gao J. An K. Lee J. M. Edwards G. E. An G. (1996). Promoter elements controlling developmental and environmental regulation of a tobacco ribosomal protein gene L34. Plant Mol. Biol. 32, 1055–1065.10.1007/BF00041389 9002604 [PubMed] [DOI]

de Moura E. G. Lisboa P. C. Passos M. C. (2008). Neonatal programming of neuroimmunomodulation role of adipocytokines and neuropeptides. Neuroimmunomodulation 15, 176–188.10.1159/000153422 18781082 [OpenAIRE] [PubMed] [DOI]

de Oliveira E. de Moura E. G. Santos-Silva A. P. Pinheiro C. R. Claudio-Neto S. Christian Manhães A. (2011). Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw. Food Chem. Toxicol. 49, 2068–2073.10.1016/j.fct.2011.04.040 21624425 [OpenAIRE] [PubMed] [DOI]

de Oliveira E. Moura E. G. Santos-Silva A. P. Pinheiro C. R. Lima N. S. Nogueira-Neto J. F. (2010). Neonatal nicotine exposure causes insulin and leptin resistance and inhibits hypothalamic leptin signaling in adult rats offspring. J. Endocrinol. 206, 55–63.10.1677/JOE-10-0104 20453077 [PubMed] [DOI]

DiFranza J. R. Lew R. A. (1995). Effect of maternal cigarette smoking on pregnancy complications and sudden infant death syndrome. J. Fam. Pract. 40, 385–394.7699353 [PubMed]

107 references, page 1 of 8
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue