publication . Article . Other literature type . 1993

Effects of Cu-Zn Superoxide Dismutase Overexpression on Life Span and Resistance to Oxidative Stress in Transgenic Drosophila melanogaster

Orr, W.C.; Sohal, R.S.;
  • Published: 01 Feb 1993
Abstract
Abstract Reactive oxygen species have been postulated to be a causal factor in the aging process due to their ability to inflict molecular damage. The role of the enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase; EC 1.15.1.1), which scavenges superoxide anion radicals, as a longevity determinant was examined in transgenic Drosophila melanogaster. A genomic fragment containing the Drosophila Cu-Zn SOD gene was introduced into the germ cells via a P element containing Casper vector. In different transgenic lines, overexpression of SOD by 32-42% above normal had either a minor and/or an insignificant effect on life span of th...
Subjects
free text keywords: Biophysics, Biochemistry, Molecular Biology, Hyperoxia, medicine.symptom, medicine, Superoxide dismutase, biology.protein, biology, Paraquat, chemistry.chemical_compound, chemistry, Oxidative stress, medicine.disease_cause, Superoxide, Reactive oxygen species, chemistry.chemical_classification, Maximum life span, Drosophila melanogaster, biology.organism_classification
Related Organizations
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue