publication . Article . Other literature type . 2004

The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre.

Menon Rajesh P.; Gibson Toby J.; Pastore Annalisa;
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  • Published: 01 Oct 2004 Journal: Journal of Molecular Biology, volume 343, pages 43-53 (issn: 0022-2836, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Absence of the fragile X mental retardation protein (FMRP) causes fragile X syndrome, the most common form of hereditary mental retardation. FMRP is a mainly cytoplasmic protein thought to be involved in repression of translation, through a complex network of protein–protein and protein–RNA interactions. Most of the currently known protein partners of FMRP recognise the conserved N terminus of the protein. No interaction has yet been mapped to the highly charged, poorly conserved C terminus, so far thought to be involved in RNA recognition through an RGG motif. In the present study, we show that a two-hybrid bait containing residues 419–632 of human FMRP fishes ...
Subjects
Medical Subject Headings: congenital, hereditary, and neonatal diseases and abnormalitiesnervous system diseases
free text keywords: Molecular Biology, Sequence analysis, Fragile X syndrome, medicine.disease, medicine, Genetics, Biology, C-terminus, RNA, Psychological repression, Cerebral cortex, medicine.anatomical_structure, RNA-binding protein, N-terminus
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