publication . Article . Other literature type . 1999

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

Felsher, D. W.; Bishop, J. M.;
Open Access
  • Published: 30 Mar 1999 Journal: Proceedings of the National Academy of Sciences, volume 96, pages 3,940-3,944 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Overexpression of the MYC protooncogene has been implicated in the genesis of diverse human tumors. Tumorigenesis induced by MYC has been attributed to sustained effects on proliferation and differentiation. Here we report that MYC may also contribute to tumorigenesis by destabilizing the cellular genome. A transient excess of MYC activity increased tumorigenicity of Rat1A cells by at least 50-fold. The increase persisted for >30 days after the return of MYC activity to normal levels. The brief surfeit of MYC activity was accompanied by evidence of genomic instability, including karyotypic abnormalities, gene amplification, and hypersensitivity to DNA-damaging a...
Subjects
free text keywords: Karyotype, Cell culture, Genome instability, Stimulation, Transfection, Carcinogenesis, medicine.disease_cause, medicine, Biology, Genome, Cancer research, Gene duplication, Biological Sciences
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publication . Article . Other literature type . 1999

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

Felsher, D. W.; Bishop, J. M.;