publication . Other literature type . Article . 1991

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

R. A. DeFronzo; E. Ferrannini;
  • Published: 01 Mar 1991
  • Publisher: American Diabetes Association
Abstract
Diabetes mellitus is commonly associated with systolic/diastolic hypertension, and a wealth of epidemiological data suggest that this association is independent of age and obesity. Much evidence indicates that the link between diabetes and essential hypertension is hyperinsulinemia. Thus, when hypertensive patients, whether obese or of normal body weight, are compared with age- and weight-matched normotensive control subjects, a heightened plasma insulin response to a glucose challenge is consistently found. A state of cellular resistance to insulin action subtends the observed hyperinsulinism. With the insulin/glucose-clamp technique, in combination with tracer...
Subjects
free text keywords: Endocrinology, medicine.medical_specialty, medicine, Internal medicine, business.industry, business, Pathophysiology of hypertension, medicine.disease, Insulin resistance, Essential hypertension, Diabetes mellitus, Hyperinsulinism, Hyperinsulinemia, Dyslipidemia, Insulin, medicine.medical_treatment
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publication . Other literature type . Article . 1991

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

R. A. DeFronzo; E. Ferrannini;