publication . Other literature type . Article . 2011

Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia

M. Elamin; J. Phukan; P. Bede; N. Jordan; S. Byrne; N. Pender; O. Hardiman;
  • Published: 04 Apr 2011
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
Background: The prognostic implications of cognitive impairment in amyotrophic lateral sclerosis (ALS) are not established. Objectives: To investigate the survival effect of the comorbid frontotemporal dementia (FTD) and to determine whether, in the absence of dementia, impairment in different cognitive domains affects outcome. Methods: A prospective population-based study of incident cases of ALS in the Republic of Ireland included home-based neuropsychological assessments using age-, sex-, and education-matched controls. Four cognitive domains were evaluated: executive function, memory, language, and visuospatial skills. Results: Mean age of the participants (...
Subjects
free text keywords: Clinical Neurology, Clinical psychology, Amyotrophic lateral sclerosis, medicine.disease, medicine, Cognition, Internal medicine, medicine.medical_specialty, Executive dysfunction, Hazard ratio, Neuropsychology, Physical therapy, business.industry, business, Population, education.field_of_study, education, Frontotemporal dementia, Dementia
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