publication . Other literature type . Article . 2012

Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers

Quiroz Y. T.; Stern C. E.; Reiman E. M.; Brickhouse M.; Ruiz A.; Sperling R. A.; Lopera F.; Dickerson B. C.;
  • Published: 07 Nov 2012
  • Publisher: BMJ
Abstract
Background Sporadic late-onset Alzheimer9s disease (AD) dementia has been associated with a ‘signature’ of cortical atrophy in paralimbic and heteromodal association regions measured with MRI. Objective To investigate whether a similar pattern of cortical atrophy is present in presymptomatic presenilin 1 E280A mutation carriers an average of 6 years before clinical symptom onset. Methods 40 cognitively normal volunteers from a Colombian population with familial AD were included; 18 were positive for the AD-associated presenilin 1 mutation (carriers, mean age=38) whereas 22 were non-carriers. T1-weighted volumetric MRI images were acquired and cortical thickness ...
Subjects
free text keywords: Article, Surgery, Psychiatry and Mental health, Clinical Neurology, Dementia, medicine.disease, medicine, Neuroscience, Cerebral cortex, medicine.anatomical_structure, business.industry, business, Cortex (botany), Pathology, medicine.medical_specialty, Magnetic resonance imaging, medicine.diagnostic_test, Atrophy, Presenilin, Alzheimer's disease, Population, education.field_of_study, education
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2012

Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers

Quiroz Y. T.; Stern C. E.; Reiman E. M.; Brickhouse M.; Ruiz A.; Sperling R. A.; Lopera F.; Dickerson B. C.;