publication . Article . Other literature type . 2005

Quercetin Decreases Oxidative Stress, NF-κB Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats

Dias, A. S.; Porawski, M.; Alonso, M.; Marroni, N.; Collado, P. S.; Javier González-Gallego;
  • Published: 01 Sep 2005
Abstract
Increasing evidence in both experimental and clinical studies suggests that oxidative stress is involved in the pathogenesis and progression of diabetic tissue damage. This study investigated the protective effects of quercetin treatment on oxidative stress, nuclear factor (NF)-B activation and expression of inducible nitric oxide synthase (iNOS) in streptozotocin-induced diabetic rats. Male Wistar rats were divided into 4 groups: control rats, control rats treated daily with quercetin (150 mol/kg, i.p.), untreated diabetic rats, and diabetic rats treated with quercetin. Diabetes was induced by a single i.p. injection of streptozotocin (70 mg/kg). Eight weeks la...
Subjects
free text keywords: Nutrition and Dietetics, Medicine (miscellaneous), Nitric oxide, chemistry.chemical_compound, chemistry, Superoxide dismutase, biology.protein, biology, Internal medicine, medicine.medical_specialty, medicine, Streptozotocin, medicine.drug, Nitric oxide synthase, Endocrinology, Quercetin, TBARS, Biochemistry, Catalase, Oxidative stress, medicine.disease_cause
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