publication . Article . 2016

Matrine induces Akt/mTOR signalling inhibition‐mediated autophagy and apoptosis in acute myeloid leukaemia cells

Wu, Junqing; Hu, Gang; Dong, Yuqing; Ma, Ruye; Yu, Zhijie; Jiang, Songfu; Han, Yixiang; Yu, Kang; Zhang, Shenghui;
Open Access
  • Published: 01 Dec 2016 Journal: Journal of Cellular and Molecular Medicine, volume 21, pages 1,171-1,181 (issn: 1582-1838, Copyright policy)
  • Publisher: Wiley
Abstract
Abstract Pharmacological modulation of autophagy has been referred to as a promising therapeutic strategy for cancer. Matrine, a main alkaloid extracted from Sophora flavescens Ait, has antitumour activity against acute myelocytic leukaemia (AML). Whether autophagy is involved in antileukaemia activity of matrine remains unobvious. In this study, we demonstrated that matrine inhibited cell viability and colony formation via inducing apoptosis and autophagy in AML cell lines HL‐60, THP‐1 and C1498 as well as primary AML cells. Matrine promoted caspase‐3 and PARP cleavage dose‐dependently. Matrine up‐regulated the level of LC3‐II and down‐regulated the level of SQ...
Subjects
free text keywords: Apoptosis, Biochemistry, Autophagy, Biology, PI3K/AKT/mTOR pathway, Cancer research, Molecular biology, Viability assay, Protein kinase B, Cytotoxicity, Matrine, chemistry.chemical_compound, chemistry, Poly ADP ribose polymerase, Original Article, Original Articles, acute myeloid leukaemia, Akt, mTOR
Related Organizations
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publication . Article . 2016

Matrine induces Akt/mTOR signalling inhibition‐mediated autophagy and apoptosis in acute myeloid leukaemia cells

Wu, Junqing; Hu, Gang; Dong, Yuqing; Ma, Ruye; Yu, Zhijie; Jiang, Songfu; Han, Yixiang; Yu, Kang; Zhang, Shenghui;