publication . Article . 2017

Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese.

Hongbing Shen; Yuanfeng Li; Pengbo Cao;
Open Access
  • Published: 21 Apr 2017 Journal: Scientific Reports, volume 7 (eissn: 2045-2322, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
The sodium taurocholate cotransporting polypeptide (NTCP) encoded by SLC10A1 was recently demonstrated to be a functional receptor for hepatitis B virus (HBV). The role of SLC10A1 polymorphisms, particularly the Ser267Phe variant (rs2296651) in exon 4, has been frequently investigated in regard to risk of persistent HBV infection. However, these investigations have generated conflicting results. To examine whether common genetic variation at the SLC10A1 locus is associated with risk of persistent HBV infection, haplotype-tagging and imputed single nucleotide polymorphisms (SNPs) were assessed in two case-control sample sets, totally including 2,550 cases (persis...
Subjects
free text keywords: Multidisciplinary, Article
Related Organizations
56 references, page 1 of 4

Schweitzer A., Horn J., Mikolajczyk R. T., Krause G. & Ott J. J. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 386, 1546–55 (2015).26231459 [PubMed]

Chu C. J. & Lok A. S. Clinical significance of hepatitis B virus genotypes. Hepatology 35, 1274–6 (2002).11981779 [PubMed]

Thursz M.Genetic susceptibility in chronic viral hepatitis. Antiviral Res 52, 113–6 (2001).11672820 [PubMed]

Hann H. W., Kim C. Y., London W. T., Whitford P. & Blumberg B. S. Hepatitis B virus and primary hepatocellular carcinoma: family studies in Korea. Int J Cancer 30, 47–51 (1982).6288579 [OpenAIRE] [PubMed]

Lin T. M.. Hepatitis B virus markers in Chinese twins. Anticancer Res 9, 737–41 (1989).2764519 [PubMed]

Kamatani Y.. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41, 591–5 (2009).19349983 [OpenAIRE] [PubMed]

Mbarek H.. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet 20, 3884–92 (2011).21750111 [OpenAIRE] [PubMed]

Kim Y. J.. A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. Hum Mol Genet 22, 4233–8 (2013).23760081 [PubMed]

Hu Z.. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nat Genet 45, 1499–503 (2013).24162738 [OpenAIRE] [PubMed]

Li Y.. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nat Commun 7, 11664 (2016).27244555 [OpenAIRE] [PubMed]

Hohler T.. A tumor necrosis factor-alpha (TNF-alpha) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol 111, 579–82 (1998).9528902 [OpenAIRE] [PubMed]

Mareninova O.. Topography of the membrane domain of the liver Na+-dependent bile acid transporter. Biochemistry 44, 13702–12 (2005).16229460 [OpenAIRE] [PubMed]

Stieger B.. In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology 107, 1781–7 (1994).7958692 [OpenAIRE] [PubMed]

Yan H.. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. elife 1, e00049 (2012).23150796 [OpenAIRE] [PubMed]

Yan H.. Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol 87, 7977–91 (2013).23678176 [OpenAIRE] [PubMed]

56 references, page 1 of 4
Abstract
The sodium taurocholate cotransporting polypeptide (NTCP) encoded by SLC10A1 was recently demonstrated to be a functional receptor for hepatitis B virus (HBV). The role of SLC10A1 polymorphisms, particularly the Ser267Phe variant (rs2296651) in exon 4, has been frequently investigated in regard to risk of persistent HBV infection. However, these investigations have generated conflicting results. To examine whether common genetic variation at the SLC10A1 locus is associated with risk of persistent HBV infection, haplotype-tagging and imputed single nucleotide polymorphisms (SNPs) were assessed in two case-control sample sets, totally including 2,550 cases (persis...
Subjects
free text keywords: Multidisciplinary, Article
Related Organizations
56 references, page 1 of 4

Schweitzer A., Horn J., Mikolajczyk R. T., Krause G. & Ott J. J. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 386, 1546–55 (2015).26231459 [PubMed]

Chu C. J. & Lok A. S. Clinical significance of hepatitis B virus genotypes. Hepatology 35, 1274–6 (2002).11981779 [PubMed]

Thursz M.Genetic susceptibility in chronic viral hepatitis. Antiviral Res 52, 113–6 (2001).11672820 [PubMed]

Hann H. W., Kim C. Y., London W. T., Whitford P. & Blumberg B. S. Hepatitis B virus and primary hepatocellular carcinoma: family studies in Korea. Int J Cancer 30, 47–51 (1982).6288579 [OpenAIRE] [PubMed]

Lin T. M.. Hepatitis B virus markers in Chinese twins. Anticancer Res 9, 737–41 (1989).2764519 [PubMed]

Kamatani Y.. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41, 591–5 (2009).19349983 [OpenAIRE] [PubMed]

Mbarek H.. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet 20, 3884–92 (2011).21750111 [OpenAIRE] [PubMed]

Kim Y. J.. A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. Hum Mol Genet 22, 4233–8 (2013).23760081 [PubMed]

Hu Z.. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nat Genet 45, 1499–503 (2013).24162738 [OpenAIRE] [PubMed]

Li Y.. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nat Commun 7, 11664 (2016).27244555 [OpenAIRE] [PubMed]

Hohler T.. A tumor necrosis factor-alpha (TNF-alpha) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol 111, 579–82 (1998).9528902 [OpenAIRE] [PubMed]

Mareninova O.. Topography of the membrane domain of the liver Na+-dependent bile acid transporter. Biochemistry 44, 13702–12 (2005).16229460 [OpenAIRE] [PubMed]

Stieger B.. In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology 107, 1781–7 (1994).7958692 [OpenAIRE] [PubMed]

Yan H.. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. elife 1, e00049 (2012).23150796 [OpenAIRE] [PubMed]

Yan H.. Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol 87, 7977–91 (2013).23678176 [OpenAIRE] [PubMed]

56 references, page 1 of 4
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