publication . Other literature type . Article . 2006

Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination

Peter C. Doherty; Peter C. Doherty; David Price; Katherine Kedzierska; Vanessa Venturi; Miles P. Davenport; Stephen J. Turner; Daniel C. Douek;
Open Access
  • Published: 27 Nov 2006
  • Publisher: Proceedings of the National Academy of Sciences
  • Country: United Kingdom
Abstract
Public responses where identical T cell receptors (TCRs) are clonally dominant and shared between different individuals are a common characteristic of CD8+ T cell-mediated immunity. Focusing on TCR sharing, we analyzed ≈3,400 TCR β chains (TCRβs) from mouse CD8+ T cells responding to the influenza A virus DbNP366 and DbPA224 epitopes. Both the “public” DbNP366-specific and “private” DbPA224-specific TCR repertoires contain a high proportion (≈36%) of shared TCRβs, although the numbers of mice sharing TCRβs in each repertoire varies greatly. Sharing of both the TCRβ amino acid and TCRβ nucleotide sequence was negatively correlated with the prevalence of random nu...
Subjects
free text keywords: Biological Sciences, Multidisciplinary, R1, Cytotoxic T cell, Peptide sequence, Genetics, Nucleic acid sequence, T-cell receptor, Epitope, CD8, T cell, medicine.anatomical_structure, medicine, MHC class I, biology.protein, biology
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