publication . Article . 2016

Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.

Md, Ikonomovic; Cj, Buckley; Heurling K; Sherwin P; Paul Jones; Zanette M; Ca, Mathis; We, Klunk; Chakrabarty A; Ironside J; ...
  • Published: 01 Dec 2016
Abstract
In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer’s disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject selection, and be used as an outcome measure. A recent phase III trial of [18F]flutemetamol positron emission tomography (PET) imaging in 106 end-of-life subjects demonstrated the ability to identify fibrillar β-amyloid by comparing in vivo PET to post-mortem histopathology. Post-mortem analyses demonstrated a broad and continuous spectrum of β-amyloid pathology in AD and other dementing and non-dementing disease groups. The GE067-026 trial demonstrated 91% sen...
Subjects
free text keywords: Radiology, Nuclear Medicine and Medical Imaging, Radiologi och bildbehandling, Alzheimer's disease, Research, Flutemetamol, PET, Amyloid, Alzheimer’s disease, Neuropathology (4-6 allowed), Histopathology, medicine.medical_specialty, medicine, Senile plaques, Pathology, Positron emission tomography, medicine.diagnostic_test, Flutemetamol F 18, Dementia, medicine.disease, Preclinical imaging, business.industry, business, Cerebral amyloid angiopathy
70 references, page 1 of 5

Alafuzoff, I, Pikkarainen, M, Arzberger, T, Thal, DR, Al-Sarraj, S, Bell, J, Bodi, I, Budka, H, Capetillo-Zarate, E, Ferrer, I, Gelpi, E, Gentleman, S, Giaccone, G, Kavantzas, N, King, A, Korkolopoulou, P, Kovacs, GG, Meyronet, D, Monoranu, C, Parchi, P, Patsouris, E, Roggendorf, W, Stadelmann, C, Streichenberger, N, Tagliavini, F, Kretzschmar, H. Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium. Acta Neuropathol. 2008; 115: 533-546 [OpenAIRE] [PubMed] [DOI]

Bacskai, BJ, Frosch, MP, Freeman, SH, Raymond, SB, Augustinack, JC, Johnson, KA, Irizarry, MC, Klunk, WE, Mathis, CA, DeKosky, ST, Greenberg, SM, Hyman, BT, Growdon, JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007; 64: 431-434 [OpenAIRE] [PubMed] [DOI]

Baron, JC, Farid, K, Dolan, E, Turc, G, Marrapu, ST, O'Brien, E, Aigbirhio, FI, Fryer, TD, Menon, DK, Warburton, EA, Hong, YT. Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage. J Cereb Blood Flow Metab. 2014; 34: 753-758 [OpenAIRE] [PubMed] [DOI]

Beach, TG, Monsell, SE, Phillips, LE, Kukull, W. Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010. J Neuropathol Exp Neurol. 2012; 71: 266-273 [OpenAIRE] [PubMed] [DOI]

Beach, TG, Thal, DR, Zanette, M, Smith, A, Buckley, C. Detection of striatal amyloid plaques with [18 F] flutemetamol: validation with postmortem histopathology. J Alzheimers Dis. 2016; 52: 863-873 [OpenAIRE] [PubMed] [DOI]

Biancalana, M, Koide, S. Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta. 2010; 1804: 1405-1412 [OpenAIRE] [PubMed] [DOI]

Braak, H, Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991; 82: 239-259 [PubMed] [DOI]

Braak, H, Braak, E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging. 1997; 18: 351-357 [PubMed] [DOI]

Burack, MA, Hartlein, J, Flores, HP, Taylor-Reinwald, L, Perlmutter, JS, Cairns, NJ. In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology. 2010; 74: 77-84 [OpenAIRE] [PubMed] [DOI]

Cairns, NJ, Ikonomovic, MD, Benzinger, T, Storandt, M, Fagan, AM, Shah, AR, Reinwald, LT, Carter, D, Felton, A, Holtzman, DM, Mintun, MA, Klunk, WE, Morris, JC. Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report. Arch Neurol. 2009; 66: 1557-1562 [OpenAIRE] [PubMed] [DOI]

Clark, CM, Pontecorvo, MJ, Beach, TG, Bedell, BJ, Coleman, RE, Doraiswamy, PM, Fleisher, AS, Reiman, EM, Sabbagh, MN, Sadowsky, CH, Schneider, JA, Arora, A, Carpenter, AP, Flitter, ML, Joshi, AD, Krautkramer, MJ, Lu, M, Mintun, MA, Skovronsky, DM. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: a prospective cohort study. Lancet Neurol. 2012; 11: 669-678 [OpenAIRE] [PubMed] [DOI]

Clark, CM, Schneider, JA, Bedell, BJ, Beach, TG, Bilker, WB, Mintun, MA, Pontecorvo, MJ, Hefti, F, Carpenter, AP, Flitter, ML, Krautkramer, MJ, Kung, HF, Coleman, RE, Doraiswamy, PM, Fleisher, AS, Sabbagh, MN, Sadowsky, CH, Reiman, EP, Zehntner, SP, Skovronsky, DM. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA. 2011; 305: 275-283 [OpenAIRE] [PubMed] [DOI]

Crary, JF, Trojanowski, JQ, Schneider, JA, Abisambra, JF, Abner, EL, Alafuzoff, I, Arnold, SE, Attems, J, Beach, TG, Bigio, EH, Cairns, NJ, Dickson, DW, Gearing, M, Grinberg, LT, Hof, PR, Hyman, BT, Jellinger, K, Jicha, GA, Kovacs, GG, Knopman, DS, Kofler, J, Kukull, WA, Mackenzie, IR, Masliah, E, McKee, A, Montine, TJ, Murray, ME, Neltner, JH, Santa-Maria, I, Seeley, WW, Serrano-Pozo, A, Shelanski, ML, Stein, T, Takao, M, Thal, DR, Toledo, JB, Troncoso, JC, Vonsattel, JP, White, CL, Wisniewski, T, Woltjer, RL, Yamada, M, Nelson, PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol (Berl). 2014; 128: 755-766 [OpenAIRE] [PubMed] [DOI]

Curtis, C, Gamez, JE, Singh, U, Sadowsky, CH, Villena, T, Sabbagh, MN, Beach, TG, Duara, R, Fleisher, AS, Frey, KA, Walker, Z, Hunjan, A, Holmes, C, Escovar, YM, Vera, CX, Agronin, ME, Ross, J, Bozoki, A, Akinola, M, Shi, J, Vandenberghe, R, Ikonomovic, MD, Sherwin, PF, Grachev, ID, Farrar, G, Smith, AP, Buckley, CJ, McLain, R, Salloway, S. Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 Imaging and neuritic plaque density. JAMA Neurol. 2015; 72 (3): 287-294 [OpenAIRE] [PubMed] [DOI]

Dickson, DW, Wertkin, A, Mattiace, LA, Fier, E, Kress, Y, Davies, P, Yen, SH. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer’s disease. Acta Neuropathol. 1990; 79: 486-493 [PubMed] [DOI]

70 references, page 1 of 5
Abstract
In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer’s disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject selection, and be used as an outcome measure. A recent phase III trial of [18F]flutemetamol positron emission tomography (PET) imaging in 106 end-of-life subjects demonstrated the ability to identify fibrillar β-amyloid by comparing in vivo PET to post-mortem histopathology. Post-mortem analyses demonstrated a broad and continuous spectrum of β-amyloid pathology in AD and other dementing and non-dementing disease groups. The GE067-026 trial demonstrated 91% sen...
Subjects
free text keywords: Radiology, Nuclear Medicine and Medical Imaging, Radiologi och bildbehandling, Alzheimer's disease, Research, Flutemetamol, PET, Amyloid, Alzheimer’s disease, Neuropathology (4-6 allowed), Histopathology, medicine.medical_specialty, medicine, Senile plaques, Pathology, Positron emission tomography, medicine.diagnostic_test, Flutemetamol F 18, Dementia, medicine.disease, Preclinical imaging, business.industry, business, Cerebral amyloid angiopathy
70 references, page 1 of 5

Alafuzoff, I, Pikkarainen, M, Arzberger, T, Thal, DR, Al-Sarraj, S, Bell, J, Bodi, I, Budka, H, Capetillo-Zarate, E, Ferrer, I, Gelpi, E, Gentleman, S, Giaccone, G, Kavantzas, N, King, A, Korkolopoulou, P, Kovacs, GG, Meyronet, D, Monoranu, C, Parchi, P, Patsouris, E, Roggendorf, W, Stadelmann, C, Streichenberger, N, Tagliavini, F, Kretzschmar, H. Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium. Acta Neuropathol. 2008; 115: 533-546 [OpenAIRE] [PubMed] [DOI]

Bacskai, BJ, Frosch, MP, Freeman, SH, Raymond, SB, Augustinack, JC, Johnson, KA, Irizarry, MC, Klunk, WE, Mathis, CA, DeKosky, ST, Greenberg, SM, Hyman, BT, Growdon, JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007; 64: 431-434 [OpenAIRE] [PubMed] [DOI]

Baron, JC, Farid, K, Dolan, E, Turc, G, Marrapu, ST, O'Brien, E, Aigbirhio, FI, Fryer, TD, Menon, DK, Warburton, EA, Hong, YT. Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage. J Cereb Blood Flow Metab. 2014; 34: 753-758 [OpenAIRE] [PubMed] [DOI]

Beach, TG, Monsell, SE, Phillips, LE, Kukull, W. Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010. J Neuropathol Exp Neurol. 2012; 71: 266-273 [OpenAIRE] [PubMed] [DOI]

Beach, TG, Thal, DR, Zanette, M, Smith, A, Buckley, C. Detection of striatal amyloid plaques with [18 F] flutemetamol: validation with postmortem histopathology. J Alzheimers Dis. 2016; 52: 863-873 [OpenAIRE] [PubMed] [DOI]

Biancalana, M, Koide, S. Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta. 2010; 1804: 1405-1412 [OpenAIRE] [PubMed] [DOI]

Braak, H, Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991; 82: 239-259 [PubMed] [DOI]

Braak, H, Braak, E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging. 1997; 18: 351-357 [PubMed] [DOI]

Burack, MA, Hartlein, J, Flores, HP, Taylor-Reinwald, L, Perlmutter, JS, Cairns, NJ. In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology. 2010; 74: 77-84 [OpenAIRE] [PubMed] [DOI]

Cairns, NJ, Ikonomovic, MD, Benzinger, T, Storandt, M, Fagan, AM, Shah, AR, Reinwald, LT, Carter, D, Felton, A, Holtzman, DM, Mintun, MA, Klunk, WE, Morris, JC. Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report. Arch Neurol. 2009; 66: 1557-1562 [OpenAIRE] [PubMed] [DOI]

Clark, CM, Pontecorvo, MJ, Beach, TG, Bedell, BJ, Coleman, RE, Doraiswamy, PM, Fleisher, AS, Reiman, EM, Sabbagh, MN, Sadowsky, CH, Schneider, JA, Arora, A, Carpenter, AP, Flitter, ML, Joshi, AD, Krautkramer, MJ, Lu, M, Mintun, MA, Skovronsky, DM. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: a prospective cohort study. Lancet Neurol. 2012; 11: 669-678 [OpenAIRE] [PubMed] [DOI]

Clark, CM, Schneider, JA, Bedell, BJ, Beach, TG, Bilker, WB, Mintun, MA, Pontecorvo, MJ, Hefti, F, Carpenter, AP, Flitter, ML, Krautkramer, MJ, Kung, HF, Coleman, RE, Doraiswamy, PM, Fleisher, AS, Sabbagh, MN, Sadowsky, CH, Reiman, EP, Zehntner, SP, Skovronsky, DM. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA. 2011; 305: 275-283 [OpenAIRE] [PubMed] [DOI]

Crary, JF, Trojanowski, JQ, Schneider, JA, Abisambra, JF, Abner, EL, Alafuzoff, I, Arnold, SE, Attems, J, Beach, TG, Bigio, EH, Cairns, NJ, Dickson, DW, Gearing, M, Grinberg, LT, Hof, PR, Hyman, BT, Jellinger, K, Jicha, GA, Kovacs, GG, Knopman, DS, Kofler, J, Kukull, WA, Mackenzie, IR, Masliah, E, McKee, A, Montine, TJ, Murray, ME, Neltner, JH, Santa-Maria, I, Seeley, WW, Serrano-Pozo, A, Shelanski, ML, Stein, T, Takao, M, Thal, DR, Toledo, JB, Troncoso, JC, Vonsattel, JP, White, CL, Wisniewski, T, Woltjer, RL, Yamada, M, Nelson, PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol (Berl). 2014; 128: 755-766 [OpenAIRE] [PubMed] [DOI]

Curtis, C, Gamez, JE, Singh, U, Sadowsky, CH, Villena, T, Sabbagh, MN, Beach, TG, Duara, R, Fleisher, AS, Frey, KA, Walker, Z, Hunjan, A, Holmes, C, Escovar, YM, Vera, CX, Agronin, ME, Ross, J, Bozoki, A, Akinola, M, Shi, J, Vandenberghe, R, Ikonomovic, MD, Sherwin, PF, Grachev, ID, Farrar, G, Smith, AP, Buckley, CJ, McLain, R, Salloway, S. Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 Imaging and neuritic plaque density. JAMA Neurol. 2015; 72 (3): 287-294 [OpenAIRE] [PubMed] [DOI]

Dickson, DW, Wertkin, A, Mattiace, LA, Fier, E, Kress, Y, Davies, P, Yen, SH. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer’s disease. Acta Neuropathol. 1990; 79: 486-493 [PubMed] [DOI]

70 references, page 1 of 5
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