publication . Article . Other literature type . 2019

Threat Memory Reminder Under Matrix Metalloproteinase 9 Inhibitor Doxycycline Globally Reduces Subsequent Memory Plasticity.

Dominik R Bach; Boris B. Quednow; Shiva Tyagarajan;
Open Access English
  • Published: 15 Oct 2019 Journal: The Journal of Neuroscience, volume 39, issue 47, pages 9,424-9,434 (issn: 0270-6474, eissn: 1529-2401, Copyright policy)
  • Publisher: Society for Neuroscience
Abstract
Associative memory can be rendered malleable by a reminder. Blocking the ensuing reconsolidation process is suggested as a therapeutic target for unwanted aversive memories. Matrix metalloproteinase-9 (MMP-9) is required for structural synapse remodeling involved in memory consolidation. Inhibiting MMP-9 with doxycycline is suggested to attenuate human threat conditioning. Here, we investigated whether MMP-9 inhibition also interferes with threat memory reconsolidation. Male and female human participants (N = 78) learned the association between two visual conditioned stimuli (CS+) and a 50% chance of an unconditioned nociceptive stimulus (US), and between CS− an...
Subjects
Medical Subject Headings: education
free text keywords: Institute of Pharmacology and Toxicology, Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Neuroscience Center Zurich, 570 Life sciences; biology, 610 Medicine & health, Research Articles, Behavioral/Cognitive, fear-potentiated startle, matrix metalloproteinase, psychophysiological modeling, reconsolidation, threat conditioning, trauma-related disorder, General Neuroscience
77 references, page 1 of 6

Abrous DN, Wojtowicz JM (2015) Interaction between neurogenesis and hippocampal memory system: new vistas. Cold Spring Harb Perspect Biol 7:a018952. 10.1101/cshperspect.a018952 26032718 [OpenAIRE] [PubMed] [DOI]

Bach DR, Friston KJ (2013) Model-based analysis of skin conductance responses: towards causal models in psychophysiology. Psychophysiology 50:15–22. 10.1111/j.1469-8986.2012.01483.x 23094650 [OpenAIRE] [PubMed] [DOI]

Bach DR, Flandin G, Friston K, Dolan RJ (2009) Time-series analysis for rapid event-related skin conductance responses. J Neurosci Methods 184 224–234.19686778 [OpenAIRE] [PubMed]

Bach DR, Daunizeau J, Friston KJ, Dolan RJ (2010a) Dynamic causal modeling of anticipatory skin conductance responses. Biological Psychology 85:163–170. 10.1016/j.biopsycho.2010.06.007 20599582 [OpenAIRE] [PubMed] [DOI]

Bach DR, Flandin G, Friston KJ, Dolan RJ (2010b) Modeling event-related skin conductance responses. International Journal of Psychophysiology 75:349–356. 10.1016/j.ijpsycho.2010.01.005 20093150 [OpenAIRE] [PubMed] [DOI]

Bach DR, Tzovara A, Vunder J (2018a) Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline. Molecular Psychiatry 23:1584–1589. 10.1038/mp.2017.65 28373691 [OpenAIRE] [PubMed] [DOI]

Bach DR, Castegnetti G, Korn CW, Gerster S, Melin scak F, Moser T (2018b) Psychophysiological modeling: current state and future directions. Psychophysiology 55:e13214. 10.1111/psyp.13209 30175471 [OpenAIRE] [PubMed] [DOI]

Banerjee SB, Gutzeit VA, Baman J, Aoued HS, Doshi NK, Liu RC, Ressler KJ (2017) Perineuronal nets in the adult sensory cortex are necessary for fear learning. Neuron 95:169–179.e3. 10.1016/j.neuron.2017.06.007 28648500 [OpenAIRE] [PubMed] [DOI]

Besnard A, Caboche J, Laroche S (2012) Reconsolidation of memory: a decade of debate. Prog Neurobiol 99:61–80. 10.1016/j.pneurobio.2012.07.002 22877586 [OpenAIRE] [PubMed] [DOI]

Bijata M, Labus J, Guseva D, Stawarski M, Butzlaff M, Dzwonek J, Schneeberg J, Böhm K, Michaluk P, Rusakov DA, Dityatev A, Wilczyński G, Wlodarczyk J, Ponimaskin E (2017) Synaptic remodeling depends on signaling between serotonin receptors and the extracellular matrix. Cell Rep 19:1767–1782. 10.101 6/j.celrep.2017.05.023 28564597 [OpenAIRE] [PubMed] [DOI]

Blumenthal TD, Cuthbert BN, Filion DL, Hackley S, Lipp OV, van Boxtel A (2005) Committee report: guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42:1–15. 10.1111/j.1469-8986.2005.00271.x 15720576 [OpenAIRE] [PubMed] [DOI]

Brown TE, Wilson AR, Cocking DL, Sorg BA (2009) Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory. Neurobiol Learn Mem 91:66–72. 10.1016/j.nlm.2008.09.003 18824238 [OpenAIRE] [PubMed] [DOI]

Brunet A, Saumier D, Liu A, Streiner DL, Tremblay J, Pitman RK (2018) Reduction of PTSD symptoms with pre-reactivation propranolol therapy: a randomized controlled trial. Am J Psychiatry 175:427–433. 10.1176/appi.ajp.2017.17050481 29325446 [OpenAIRE] [PubMed] [DOI]

Brünig I, Suter A, Knuesel I, Lüscher B, Fritschy JM (2002) GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin. J Neurosci 22:4805–4813. 10.1523/JNEUROSCI.22-12-04805.2002 12077177 [OpenAIRE] [PubMed] [DOI]

Castegnetti G, Tzovara A, Staib M, Paulus PC, Hofer N, Bach DR (2016) Modeling fear-conditioned bradycardia in humans. Psychophysiology 53:930–939. 10.1111/psyp.12637 26950648 [OpenAIRE] [PubMed] [DOI]

77 references, page 1 of 6
Abstract
Associative memory can be rendered malleable by a reminder. Blocking the ensuing reconsolidation process is suggested as a therapeutic target for unwanted aversive memories. Matrix metalloproteinase-9 (MMP-9) is required for structural synapse remodeling involved in memory consolidation. Inhibiting MMP-9 with doxycycline is suggested to attenuate human threat conditioning. Here, we investigated whether MMP-9 inhibition also interferes with threat memory reconsolidation. Male and female human participants (N = 78) learned the association between two visual conditioned stimuli (CS+) and a 50% chance of an unconditioned nociceptive stimulus (US), and between CS− an...
Subjects
Medical Subject Headings: education
free text keywords: Institute of Pharmacology and Toxicology, Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Neuroscience Center Zurich, 570 Life sciences; biology, 610 Medicine & health, Research Articles, Behavioral/Cognitive, fear-potentiated startle, matrix metalloproteinase, psychophysiological modeling, reconsolidation, threat conditioning, trauma-related disorder, General Neuroscience
77 references, page 1 of 6

Abrous DN, Wojtowicz JM (2015) Interaction between neurogenesis and hippocampal memory system: new vistas. Cold Spring Harb Perspect Biol 7:a018952. 10.1101/cshperspect.a018952 26032718 [OpenAIRE] [PubMed] [DOI]

Bach DR, Friston KJ (2013) Model-based analysis of skin conductance responses: towards causal models in psychophysiology. Psychophysiology 50:15–22. 10.1111/j.1469-8986.2012.01483.x 23094650 [OpenAIRE] [PubMed] [DOI]

Bach DR, Flandin G, Friston K, Dolan RJ (2009) Time-series analysis for rapid event-related skin conductance responses. J Neurosci Methods 184 224–234.19686778 [OpenAIRE] [PubMed]

Bach DR, Daunizeau J, Friston KJ, Dolan RJ (2010a) Dynamic causal modeling of anticipatory skin conductance responses. Biological Psychology 85:163–170. 10.1016/j.biopsycho.2010.06.007 20599582 [OpenAIRE] [PubMed] [DOI]

Bach DR, Flandin G, Friston KJ, Dolan RJ (2010b) Modeling event-related skin conductance responses. International Journal of Psychophysiology 75:349–356. 10.1016/j.ijpsycho.2010.01.005 20093150 [OpenAIRE] [PubMed] [DOI]

Bach DR, Tzovara A, Vunder J (2018a) Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline. Molecular Psychiatry 23:1584–1589. 10.1038/mp.2017.65 28373691 [OpenAIRE] [PubMed] [DOI]

Bach DR, Castegnetti G, Korn CW, Gerster S, Melin scak F, Moser T (2018b) Psychophysiological modeling: current state and future directions. Psychophysiology 55:e13214. 10.1111/psyp.13209 30175471 [OpenAIRE] [PubMed] [DOI]

Banerjee SB, Gutzeit VA, Baman J, Aoued HS, Doshi NK, Liu RC, Ressler KJ (2017) Perineuronal nets in the adult sensory cortex are necessary for fear learning. Neuron 95:169–179.e3. 10.1016/j.neuron.2017.06.007 28648500 [OpenAIRE] [PubMed] [DOI]

Besnard A, Caboche J, Laroche S (2012) Reconsolidation of memory: a decade of debate. Prog Neurobiol 99:61–80. 10.1016/j.pneurobio.2012.07.002 22877586 [OpenAIRE] [PubMed] [DOI]

Bijata M, Labus J, Guseva D, Stawarski M, Butzlaff M, Dzwonek J, Schneeberg J, Böhm K, Michaluk P, Rusakov DA, Dityatev A, Wilczyński G, Wlodarczyk J, Ponimaskin E (2017) Synaptic remodeling depends on signaling between serotonin receptors and the extracellular matrix. Cell Rep 19:1767–1782. 10.101 6/j.celrep.2017.05.023 28564597 [OpenAIRE] [PubMed] [DOI]

Blumenthal TD, Cuthbert BN, Filion DL, Hackley S, Lipp OV, van Boxtel A (2005) Committee report: guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42:1–15. 10.1111/j.1469-8986.2005.00271.x 15720576 [OpenAIRE] [PubMed] [DOI]

Brown TE, Wilson AR, Cocking DL, Sorg BA (2009) Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory. Neurobiol Learn Mem 91:66–72. 10.1016/j.nlm.2008.09.003 18824238 [OpenAIRE] [PubMed] [DOI]

Brunet A, Saumier D, Liu A, Streiner DL, Tremblay J, Pitman RK (2018) Reduction of PTSD symptoms with pre-reactivation propranolol therapy: a randomized controlled trial. Am J Psychiatry 175:427–433. 10.1176/appi.ajp.2017.17050481 29325446 [OpenAIRE] [PubMed] [DOI]

Brünig I, Suter A, Knuesel I, Lüscher B, Fritschy JM (2002) GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin. J Neurosci 22:4805–4813. 10.1523/JNEUROSCI.22-12-04805.2002 12077177 [OpenAIRE] [PubMed] [DOI]

Castegnetti G, Tzovara A, Staib M, Paulus PC, Hofer N, Bach DR (2016) Modeling fear-conditioned bradycardia in humans. Psychophysiology 53:930–939. 10.1111/psyp.12637 26950648 [OpenAIRE] [PubMed] [DOI]

77 references, page 1 of 6
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