publication . Article . 2011

Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection.

Guillaume Lafforgue; Santiago F. Elena;
Open Access English
  • Published: 15 Mar 2011
Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of the parasite, viral strains may be highly virulent without experiencing large accumulation as a consequence of immunopathological host responses. Using two strains of Tobacco etch potyvirus (TEV) that show a negative relationship between virulence and accumulation rate, we first explored the evolution of virulence and fitness traits during simple and mixed infections. Short-term evolution experiments initiated with each strain independently confirmed...
free text keywords: Parasite virulence, Experimental evolution, Local adaptation, Spore production, [SDV]Life Sciences [q-bio], Research Article, Biology, Computational Biology, Population Modeling, Infectious Disease Modeling, Systems Biology, Evolutionary Biology, Evolutionary Genetics, Microbiology, Virology, Emerging Viral Diseases, Viral Evolution, Population Biology, Theoretical Biology, Mathematics, Applied Mathematics, Complex Systems, Nonlinear Dynamics, Medicine, R, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine
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