publication . Article . Other literature type . 2005

Cellular signaling by fibroblast growth factor receptors.

V.P. Eswarakumar;
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  • Published: 01 Apr 2005 Journal: Cytokine & Growth Factor Reviews, volume 16, pages 139-149 (issn: 1359-6101, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of cellular responses induced by this large family of growth factors. A variety of human skeletal dysplasias have been linked to specific point mutations in FGFR1, FGFR2 and FGFR3 leading to severe impairment in cranial...
Subjects
free text keywords: Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Endocrinology, Diabetes and Metabolism
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