publication . Other literature type . Article . 2006

Different regional patterns of cortical thinning in Alzheimer’s disease and frontotemporal dementia

Du, An-Tao; Schuff, Norbert; Kramer, Joel H.; Rosen, Howard J.; Gorno-Tempini, Maria Luisa; Rankin, Katherine; Miller, Bruce L.; Weiner, Michael W.;
Open Access
  • Published: 21 Nov 2006
  • Publisher: Oxford University Press (OUP)
Abstract
Alzheimer's disease and frontotemporal dementia (FTD) can be difficult to differentiate clinically because of overlapping symptoms. Distinguishing the two dementias based on volumetric measurements of brain atrophy with MRI has been only partially successful. Whether MRI measurements of cortical thinning improve the differentiation between Alzheimer's disease and FTD is unclear. In this study, we measured cortical thick- ness using a set of automated tools (Freesurfer) to reconstruct the brain's cortical surface from T1-weighted structural MRI data in 22 patients with Alzheimer's disease, 19 patients with FTD and 23 cognitively normal subjects.The goals were to ...
Subjects
Medical Subject Headings: mental disorders
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