publication . Other literature type . Article . 2009

Ubiquitin-binding domains — from structures to functions

Dikic, Ivan; Wakatsuki, Soichi; Walters, Kylie J.;
Open Access English
  • Published: 01 Oct 2009
Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Recent atomic-level resolution structures of ubiquitin–UBD complexes have revealed some of the mechanisms that underlie the versatile functions of ubiquitin in vivo. The preferences of UBDs for ubiquitin chains of specific length and linkage are central contributors to these functions. These preferences originate from multimeric interactions, whereby UBDs synergistically bind multiple ubiquitin subunits, and from contacts with regions that link ubiquitin molecules into a polymer. The sequence context of UBDs and the conformational changes that follow...
free text keywords: Article, Cell Biology, Molecular Biology, Ubiquitin binding, Ubiquitin, biology.protein, biology
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