publication . Article . Other literature type . 2011

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

Bercik, Premysl; Denou, Emmanuel; Collins, Josh; Jackson, Wendy; Lu, Jun; Jury, Jennifer; Deng, Yikang; Blennerhassett, Patricia; Macri, Joseph; McCoy, Kathy D.; ...
Open Access
  • Published: 01 Aug 2011 Journal: Gastroenterology, volume 141, issue 2, pages 599-609
Abstract
Background & Aims Alterations in the microbial composition of the gastrointestinal tract (dysbiosis) are believed to contribute to inflammatory and functional bowel disorders and psychiatric comorbidities. We examined whether the intestinal microbiota affects behavior and brain biochemistry in mice. Methods Specific pathogen–free (SPF) BALB/c mice, with or without subdiaphragmatic vagotomy or chemical sympathectomy, or germ-free BALB/c mice received a mixture of nonabsorbable antimicrobials (neomycin, bacitracin, and pimaricin) in their drinking water for 7 days. Germ-free BALB/c and NIH Swiss mice were colonized with microbiota from SPF NIH Swiss or BALB/c mice...
Funded by
SNSF| Investigation into the impact of environmental microbes on regulation of IgE and allergic disease
Project
  • Funder: Swiss National Science Foundation (SNSF)
  • Project Code: 310030_134902
  • Funding stream: Project funding | Project funding (Div. I-III)
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