publication . Article . Other literature type . 1997

Multilocus Genotypes, a Tree of Individuals, and Human Evolutionary History

Luigi Luca Cavalli-Sforza; Joanna L. Mountain;
Open Access
  • Published: 01 Sep 1997 Journal: The American Journal of Human Genetics, volume 61, issue 3, pages 705-718 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
SummaryOur goal is to infer, from human genetic data, general patterns as well as details of human evolutionary history. Here we present the results of an analysis of genetic data at the level of the individual. A tree relating 144 individuals from 12 human groups of Africa, Asia, Europe, and Oceania, inferred from an average of 75 DNA polymorphisms/individual, is remarkable in that most individuals cluster with other members of their regional group. In order to interpret this tree, we consider the factors that influence the tree pattern, including the number of genetic loci examined, the length of population isolation, the sampling process, and the extent of ge...
Subjects
free text keywords: Genetics(clinical), Genetics, Research Article, Ancestor, Multilocus genotype, Phylogenetics, Gene flow, Genetic marker, Population genetics, Genotype, Biology, Locus (genetics)
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