publication . Article . 2002

Fibrillary glomerulonephritis and immunotactoid (microtubular) glomerulopathy are associated with distinct immunologic features

Frank Bridoux; Valerie Hugue; Olivier Coldefy; Jean-Michel Goujon; Marc Bauwens; Anne Sechet; Jean-Louis Preud'homme; Guy Touchard;
Open Access
  • Published: 01 Nov 2002 Journal: Kidney International, volume 62, pages 1,764-1,775 (issn: 0085-2538, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Fibrillary glomerulonephritis and immunotactoid (microtubular) glomerulopathy are associated with distinct immunologic features. Background The clinical relevance of distinguishing two types of glomerulonephritis (GN) with non-amyloid organized immunoglobulin (Ig) deposits—fibrillary GN (FGN) and immunotactoid (microtubular) GN (IT/MTGN)—on the basis of ultrastructural organization, is debated. Methods Twenty-three patients with organized glomerular Ig deposits were classified into two groups based on the fibrillar or microtubular ultrastructural appearance of the deposits. Kidney biopsy samples were studied by immunofluorescence microscopy, using anti-light cha...
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free text keywords: Nephrology, monoclonal gammapathy, ultrastructure of GN, non-amyloid glomerulopathies, morphology of Ig deposits, Nephropathy, medicine.disease, medicine, Monoclonal, Glomerulopathy, Nephrotic syndrome, Paraproteinemia, Glomerular deposits, Biology, Fibrillary Glomerulonephritis, Glomerulonephritis, Pathology, medicine.medical_specialty
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