publication . Article . 2000

Power of selective genotyping in genetic association analyses of quantitative traits.

Sofie Van Gestel; Jeanine J. Houwing-Duistermaat; Rolf Adolfsson; Cornelia M. van Duijn; Christine Van Broeckhoven;
Closed Access English
  • Published: 01 Jan 2000 Journal: Behavior genetics (issn: 0001-8244, Copyright policy)
  • Country: Belgium
Abstract
A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion ...
Subjects
free text keywords: Genetics, Allele, Explained variation, Genetic association, Genotyping, Sample size determination, Quantitative trait locus, Allele frequency, Quantitative genetics, Psychology
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