publication . Article . Other literature type . 2015

Cognitive Impairment in Chinese Patients with Sporadic Amyotrophic Lateral Sclerosis

Bo Cui; Liying Cui; Jing Gao; Mingsheng Liu; Xiaoguang Li; Caiyan Liu; Junfang Ma; Jia Fang;
Open Access
  • Published: 14 Sep 2015 Journal: PLOS ONE, volume 10, page e0137921 (eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Background It has reached a consensus that patients with amyotrophic lateral sclerosis (ALS) could display cognitive impairment characterized by executive dysfunction or even dementia, but cognitive spectrum of Chinese patients with ALS still waits to be documented. Methods A total of 106 incident patients with sporadic ALS were enrolled and comprehensive neuropsychological tests covering memory, executive function, attention, language, and visuospatial function were administered to them. Neuropsychological performances of 76 age- and education- matched healthy controls were used for the purpose of classification and comparison. Results 106 patients were categor...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Neuropsychology, Dementia, medicine.disease, medicine, Cognition, Psychiatry, medicine.medical_specialty, Pediatrics, Normal cognition, Executive dysfunction, Amyotrophic lateral sclerosis, business.industry, business, Cognitive neuroscience, Cognitive impairment, Research Article, R, Science, Q
Related Organizations
35 references, page 1 of 3

1 Nübling GS, Mie E, Bauer RM, Hensler M, Lorenzl S, Hapfelmeier A, et al Increased prevalence of bladder and intestinal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15:174–9. 10.3109/21678421.2013.868001 24479577 [OpenAIRE] [PubMed] [DOI]

2 McCluskey L, Vandriel S, Elman L, Van Deerlin VM, Powers J, Boller A, et al ALS-Plus syndrome: non-pyramidal features in a large ALS cohort. J Neurol Sci. 2014;345:118–24. 10.1016/j.jns.2014.07.022 25086858 [OpenAIRE] [PubMed] [DOI]

3 Murphy JM, Henry RG, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C. Continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol. 2007;64:530–4. 17420314 [PubMed]

4 Phukan J, Pender NP, Hardiman O. Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol. 2007;6:994–1003. 17945153 [OpenAIRE] [PubMed]

5 Lomen-Hoerth C.Clinical phenomenology and neuroimaging correlates in ALS-FTD. J Mol Neurosci. 2011;45:656–62. 10.1007/s12031-011-9636-x 21971978 [OpenAIRE] [PubMed] [DOI]

6 Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, et al Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009;10:131–46. 19462523 [OpenAIRE] [PubMed]

7 Oh SI, Park A, Kim HJ, Oh KW, choi H, Kwon MJ, et al Spectrum of Cognitive Imp airment in Korean ALS Patients without Known Genetic Mutations. PloS One. 2014;9:e87163 10.1371/journal.pone.0087163 24498297 [OpenAIRE] [PubMed] [DOI]

8 Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, et al The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry. 2012;83:102–8. 10.1136/jnnp-2011-300188 21836033 [OpenAIRE] [PubMed] [DOI]

9 Ringholz GM, Appel SH, Bradshaw M,Cooke NA, Mosnik DM, Schulz PE. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 2005;65:586–90. 16116120 [OpenAIRE] [PubMed]

10 Montuschi A, Iazzolino B, Calvo A, Moglia C, Lopiano L, Restagno g, et al Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy. J Neurol Neurosurg Psychiatry. 2015;86:168–73. 10.1136/jnnp-2013-307223 24769471 [OpenAIRE] [PubMed] [DOI]

11 Liu MS, Cui LY, Fan DS; Chinese ALS Association. Age at onset of amyotrophic lateral sclerosis in China. Acta Neurol Scand.2014;129:163–7. 10.1111/ane.12157 23819875 [PubMed] [DOI]

12 Cui F, Liu M, Chen Y, Huang X, Cui L, Fan D, et al Epidemiological characteristics of motor neuron disease in Chinese patients. Acta Neurol Scand. 2014;130:111–7. 10.1111/ane.12240 24689740 [OpenAIRE] [PubMed] [DOI]

13 Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci.1999;169:13–21. 10540002 [OpenAIRE] [PubMed]

14 Hillel AD, Miller RM, Yorkston K, McDonald E, Norris FH, Konikow N. Amyotrophic lateral sclerosis severity scale.Neuroepidemiology. 1989;8:142–50. 2725806 [PubMed]

15 Brooks BR, Miller RG, Swash M, Munsat TL; World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord.2000;1:293–9. 11464847 [PubMed]

35 references, page 1 of 3
Abstract
Background It has reached a consensus that patients with amyotrophic lateral sclerosis (ALS) could display cognitive impairment characterized by executive dysfunction or even dementia, but cognitive spectrum of Chinese patients with ALS still waits to be documented. Methods A total of 106 incident patients with sporadic ALS were enrolled and comprehensive neuropsychological tests covering memory, executive function, attention, language, and visuospatial function were administered to them. Neuropsychological performances of 76 age- and education- matched healthy controls were used for the purpose of classification and comparison. Results 106 patients were categor...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Neuropsychology, Dementia, medicine.disease, medicine, Cognition, Psychiatry, medicine.medical_specialty, Pediatrics, Normal cognition, Executive dysfunction, Amyotrophic lateral sclerosis, business.industry, business, Cognitive neuroscience, Cognitive impairment, Research Article, R, Science, Q
Related Organizations
35 references, page 1 of 3

1 Nübling GS, Mie E, Bauer RM, Hensler M, Lorenzl S, Hapfelmeier A, et al Increased prevalence of bladder and intestinal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15:174–9. 10.3109/21678421.2013.868001 24479577 [OpenAIRE] [PubMed] [DOI]

2 McCluskey L, Vandriel S, Elman L, Van Deerlin VM, Powers J, Boller A, et al ALS-Plus syndrome: non-pyramidal features in a large ALS cohort. J Neurol Sci. 2014;345:118–24. 10.1016/j.jns.2014.07.022 25086858 [OpenAIRE] [PubMed] [DOI]

3 Murphy JM, Henry RG, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C. Continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol. 2007;64:530–4. 17420314 [PubMed]

4 Phukan J, Pender NP, Hardiman O. Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol. 2007;6:994–1003. 17945153 [OpenAIRE] [PubMed]

5 Lomen-Hoerth C.Clinical phenomenology and neuroimaging correlates in ALS-FTD. J Mol Neurosci. 2011;45:656–62. 10.1007/s12031-011-9636-x 21971978 [OpenAIRE] [PubMed] [DOI]

6 Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, et al Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009;10:131–46. 19462523 [OpenAIRE] [PubMed]

7 Oh SI, Park A, Kim HJ, Oh KW, choi H, Kwon MJ, et al Spectrum of Cognitive Imp airment in Korean ALS Patients without Known Genetic Mutations. PloS One. 2014;9:e87163 10.1371/journal.pone.0087163 24498297 [OpenAIRE] [PubMed] [DOI]

8 Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, et al The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry. 2012;83:102–8. 10.1136/jnnp-2011-300188 21836033 [OpenAIRE] [PubMed] [DOI]

9 Ringholz GM, Appel SH, Bradshaw M,Cooke NA, Mosnik DM, Schulz PE. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 2005;65:586–90. 16116120 [OpenAIRE] [PubMed]

10 Montuschi A, Iazzolino B, Calvo A, Moglia C, Lopiano L, Restagno g, et al Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy. J Neurol Neurosurg Psychiatry. 2015;86:168–73. 10.1136/jnnp-2013-307223 24769471 [OpenAIRE] [PubMed] [DOI]

11 Liu MS, Cui LY, Fan DS; Chinese ALS Association. Age at onset of amyotrophic lateral sclerosis in China. Acta Neurol Scand.2014;129:163–7. 10.1111/ane.12157 23819875 [PubMed] [DOI]

12 Cui F, Liu M, Chen Y, Huang X, Cui L, Fan D, et al Epidemiological characteristics of motor neuron disease in Chinese patients. Acta Neurol Scand. 2014;130:111–7. 10.1111/ane.12240 24689740 [OpenAIRE] [PubMed] [DOI]

13 Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci.1999;169:13–21. 10540002 [OpenAIRE] [PubMed]

14 Hillel AD, Miller RM, Yorkston K, McDonald E, Norris FH, Konikow N. Amyotrophic lateral sclerosis severity scale.Neuroepidemiology. 1989;8:142–50. 2725806 [PubMed]

15 Brooks BR, Miller RG, Swash M, Munsat TL; World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord.2000;1:293–9. 11464847 [PubMed]

35 references, page 1 of 3
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publication . Article . Other literature type . 2015

Cognitive Impairment in Chinese Patients with Sporadic Amyotrophic Lateral Sclerosis

Bo Cui; Liying Cui; Jing Gao; Mingsheng Liu; Xiaoguang Li; Caiyan Liu; Junfang Ma; Jia Fang;