publication . Other literature type . Article . 2001

The Newly Inbred Cohen Diabetic Rat A Nonobese Normolipidemic Genetic Model of Diet-Induced Type 2 Diabetes Expressing Sex Differences

S. Weksler-Zangen; C. Yagil; D. H. Zangen; A. Ornoy; H. J. Jacob; Y. Yagil;
  • Published: 01 Nov 2001
  • Publisher: American Diabetes Association
The newly inbred Cohen diabetic rat is an exceptional experimental model of diet-induced type 2 diabetes mellitus that is the result of secondary inbreeding nearly 30 years after it originally had been established. Animals from the original colony were selectively inbred by stringent criteria for 10 additional generations, bringing overall inbreeding to >50 generations. The metabolic phenotypes of the resulting contrasting strains, designated as the Cohen diabetic-sensitive (CDs) and -resistant (CDr) rats, were characterized. The phenotype of the CDs strain that was fed a regular diet consisted of fasting normoglycemia, normal glucose tolerance to intraperitonea...
free text keywords: Insulin, medicine.medical_treatment, medicine, Weaning, Type 2 Diabetes Mellitus, Type 2 diabetes, medicine.disease, Hyperlipidemia, Diabetes mellitus, Genetic predisposition, Internal medicine, medicine.medical_specialty, Endocrinology, Genetic model, Biology
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Article . 2001
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Other literature type . 2001
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