publication . Article . 2016

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population.

Yang, Jingmin; Yang, Yuan; Xia, Mingying; Wang, Lianghui; Zhou, Weiping; Yang, Yajun; Jiang, Yueming; Wang, Hongyang; Qian, Ji; Jin, Li; ...
Open Access
  • Published: 01 Mar 2016 Journal: BMC Cancer, volume 16 (eissn: 1471-2407, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Background To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. Methods We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. Then, we performed association analyses of suggestively significant SNPs with HBV infection in 1075 controls, 1936 PSs and 639 PSEs. Results In total, 109 rare variants (74 novel) and 38 single nucleotide polymorphisms (SNPs, one novel) were screened. Of the seven non-synonymous rare variants, six were singletons and one was a double hit. All three d...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: Genetics, Cancer Research, Oncology, Research Article, HBV-receptor, NTCP, Genetic variant, HBV infection status, Association, rs4646287
Related Organizations
31 references, page 1 of 3

EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J Hepatol. 2012; 57 (1): 167-85 [OpenAIRE] [PubMed] [DOI]

Sjogren, M. Immunization and the decline of viral hepatitis as a cause of acute liver failure. Hepatology. 2003; 38 (3): 554-6 [OpenAIRE] [PubMed] [DOI]

McMahon, BJ, Holck, P, Bulkow, L, Snowball, M. Serologic and clinical outcomes of 1536 Alaska Natives chronically infected with hepatitis B virus. Ann Intern Med. 2001; 135 (9): 759-68 [OpenAIRE] [PubMed] [DOI]

Toh, QC, Tan, TL, Teo, WQ. Identification of cellular membrane proteins interacting with hepatitis B surface antigen using yeast split-ubiquitin system. Int J Med Sci. 2005; 2 (3): 114-7 [OpenAIRE] [PubMed] [DOI]

Cho, DY, Yang, GH, Ryu, CJ, Hong, HJ. Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo. J Virol. 2003; 77 (4): 2784-8 [OpenAIRE] [PubMed] [DOI]

Budkowska, A, Quan, C, Groh, F. Hepatitis B virus (HBV) binding factor in human serum: candidate for a soluble form of hepatocyte HBV receptor. J Virol. 1993; 67 (7): 4316-22 [OpenAIRE] [PubMed]

Yan, H, Zhong, G, Xu, G. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012; 1: e00049 [OpenAIRE] [PubMed] [DOI]

Zhong, G, Yan, H, Wang, H. Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes. J Virol. 2013; 87: 7176 [OpenAIRE] [PubMed] [DOI]

Drexler, JF, Geipel, A, Konig, A. Bats carry pathogenic hepadnaviruses antigenically related to hepatitis B virus and capable of infecting human hepatocytes. Proc Natl Acad Sci U S A. 2013; 110 (40): 16151-6 [OpenAIRE] [PubMed] [DOI]

Kamatani, Y, Wattanapokayakit, S, Ochi, H. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet. 2009; 41 (5): 591-5 [OpenAIRE] [PubMed] [DOI]

Jiang, DK, Sun, J, Cao, G. Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet. 2013; 45 (1): 72-5 [OpenAIRE] [PubMed] [DOI]

Li, S, Qian, J, Yang, Y. GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet. 2012; 8 (7): e1002791 [OpenAIRE] [PubMed] [DOI]

Zhang, H, Zhai, Y, Hu, Z. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet. 2010; 42 (9): 755-8 [OpenAIRE] [PubMed] [DOI]

Su, Z, Li, Y, Liao, Y. Association of the gene polymorphisms in sodium taurocholate cotransporting polypeptide with the outcomes of hepatitis B infection in Chinese Han population. Infect Genet Evol. 2014; 27: 77-82 [OpenAIRE] [PubMed] [DOI]

Peng, L, Zhao, Q, Li, Q. The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B. Hepatol. 2015; 61 (4): 1251-60 [OpenAIRE] [DOI]

31 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue