publication . Article . 2016

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population.

Yang, Jingmin; Yang, Yuan; Xia, Mingying; Wang, Lianghui; Zhou, Weiping; Yang, Yajun; Jiang, Yueming; Wang, Hongyang; Qian, Ji; Jin, Li; ...
Open Access
  • Published: 01 Mar 2016 Journal: BMC Cancer, volume 16 (eissn: 1471-2407, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Background To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. Methods We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. Then, we performed association analyses of suggestively significant SNPs with HBV infection in 1075 controls, 1936 PSs and 639 PSEs. Results In total, 109 rare variants (74 novel) and 38 single nucleotide polymorphisms (SNPs, one novel) were screened. Of the seven non-synonymous rare variants, six were singletons and one was a double hit. All three d...
Medical Subject Headings: digestive system diseases
free text keywords: Genetics, Cancer Research, Oncology, Research Article, HBV-receptor, NTCP, Genetic variant, HBV infection status, Association, rs4646287
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