publication . Article . Other literature type . 1974

On Some Principles Governing Molecular Evolution

Kimura, Motoo; Ohta, Tomoko;
Open Access
  • Published: 01 Jul 1974 Journal: Proceedings of the National Academy of Sciences, volume 71, pages 2,848-2,852 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Abstract The following five principles were deduced from the accumulated evidence on molecular evolution and theoretical considerations of the population dynamics of mutant substitutions: (i) for each protein, the rate of evolution in terms of amino acid substitutions is approximately constant/site per year for various lines, as long as the function and tertiary structure of the molecule remain essentially unaltered. (ii) Functionally less important molecules or parts of a molecule evolve (in terms of mutant substitutions) faster than more important ones. (iii) Those mutant substitutions that disrupt less the existing structure and function of a molecule (conser...
Subjects
free text keywords: Multidisciplinary, Molecular evolution, Rate of evolution, Genetics, Gene, Mutation, medicine.disease_cause, medicine, Protein tertiary structure, Biology, Mutant, Gene duplication, Population, education.field_of_study, education, Biological Sciences: Genetics
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 1974

On Some Principles Governing Molecular Evolution

Kimura, Motoo; Ohta, Tomoko;