publication . Article . Other literature type . 2008

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

Howard Aizenstein;
  • Published: 10 Nov 2008
Abstract
Objective To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, measured with a battery of neuropsychological tests. Design Subjects underwent cognitive testing and PiB PET imaging (15 mCi for 90 minutes with an ECAT HR+ scanner). Logan graphical analysis was applied to estimate regional PiB retention distribution volume, normalized to a cerebellar reference region volume, to yield distribution volume ratios (DVRs). Setting University medical center. Participants From a community-based sa...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Arts and Humanities (miscellaneous), Clinical Neurology, Gerontology, Pittsburgh compound B, chemistry.chemical_compound, chemistry, Cognitive test, Neuropsychology, Anesthesia, Population, education.field_of_study, education, Neurocognitive, Internal medicine, medicine.medical_specialty, medicine, Florbetaben, Cognitive disorder, medicine.disease, business.industry, business, Alzheimer's disease, Article
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