publication . Other literature type . Article . 2005

Energy generation in insect stages of Trypanosoma brucei: metabolism in flux

Mike Barrett; Sébastien Besteiro;
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  • Published: 01 Apr 2005
  • Publisher: Elsevier BV
Abstract
The generation of energy in African trypanosomes is a subject of undoubted importance. In bloodstream-form organisms, substrate-level phosphorylation of glucose is sufficient to provide the energy needs of the parasite. The situation in procyclic-form trypanosomes is more complex. For many years, it was accepted that glucose metabolism followed a conventional scheme involving glycolysis, the tricarboxylic acid cycle and ATP-producing oxidative phosphorylation linked to the electron-transport chain. However, progress in sequencing the Trypanosoma brucei genome and the development of gene-knockout and RNA interference technology has provided novel insight. Couplin...
Subjects
free text keywords: Parasitology, Infectious Diseases
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