publication . Article . Other literature type . 1999

A general test of association for quantitative traits in nuclear families.

Goncalo Abecasis;
Open Access
  • Published: 22 Dec 1999 Journal: The American Journal of Human Genetics, volume 66, pages 279-292 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
High-resolution mapping is an important step in the identification of complex disease genes. In outbred populations, linkage disequilibrium is expected to operate over short distances and could provide a powerful fine-mapping tool. Here we build on recently developed methods for linkage-disequilibrium mapping of quantitative traits to construct a general approach that can accommodate nuclear families of any size, with or without parental information. Variance components are used to construct a test that utilizes information from all available offspring but that is not biased in the presence of linkage or familiality. A permutation test is described for situation...
Subjects
free text keywords: Genetics(clinical), Genetics, Association, Fine-mapping, Linkage disequilibrium, Qualitative-trait locus, Single-nucleotide polymorphism, Variance components, Articles
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