publication . Article . Other literature type . 2015

Brown adipose tissue: physiological function and evolutionary significance

Elias Theodor Polymeropoulos;
  • Published: 13 May 2015 Journal: Journal of Comparative Physiology B, volume 185, pages 587-606 (issn: 0174-1578, eissn: 1432-136X, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
In modern eutherian (placental) mammals, brown adipose tissue (BAT) evolved as a specialized thermogenic organ that is responsible for adaptive non-shivering thermogenesis (NST). For NST, energy metabolism of BAT mitochondria is increased by activation of uncoupling protein 1 (UCP1), which dissipates the proton motive force as heat. Despite the presence of UCP1 orthologues prior to the divergence of teleost fish and mammalian lineages, UCP1’s significance for thermogenic adipose tissue emerged at later evolutionary stages. Recent studies on the presence of BAT in metatherians (marsupials) and eutherians of the afrotherian clade provide novel insights into the ev...
Medical Subject Headings: animal structures
free text keywords: Animal Science and Zoology, Biochemistry, Physiology, Ecology, Evolution, Behavior and Systematics, Endocrinology
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