publication . Other literature type . Article . 2007

GRAMMAR: a fast and simple method for genome-wide pedigree-based quantitative trait loci association analysis

Aulchenko, Yurii S.; de Koning, Dirk-Jan; Haley, Chris;
  • Published: 01 Sep 2007
  • Publisher: Genetics Society of America
  • Country: Netherlands
textabstractFor pedigree-based quantitative trait loci (QTL) association analysis, a range of methods utilizing within-family variation such as transmission- disequilibrium test (TDT)-based methods have been developed. In scenarios where stratification is not a concern, methods exploiting between-family variation in addition to within-family variation, such as the measured genotype (MG) approach, have greater power. Application of MG methods can be computationally demanding (especially for large pedigrees), making genomewide scans practically infeasible. Here we suggest a novel approach for genomewide pedigree-based quantitative trait loci (QTL) association anal...
free text keywords: Genetics, Biology, Genetic association, Grammar, media_common.quotation_subject, media_common, Quantitative trait locus, Genome, Computational biology, Investigations
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