publication . Article . 2018

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy.

Jia Yu-Li; Xu Meng; Dou Chang-Wei; Liu Zhi-Kui; Xue Yu-Mo; Yao Bo-Wen; Ding Ling-Long; Tu Kang-Sheng; Zheng Xin; Liu Qing-Guang;
Open Access English
  • Published: 13 Nov 2018 Journal: Cell Death & Disease, volume 7, issue 10, page e2400 (eissn: 2041-4889, Copyright policy)
  • Publisher: Nature Publishing Group
Abstract
Aberrant autophagic processes have been found to have fundamental roles in the pathogenesis of different kinds of tumors, including hepatocellular carcinoma (HCC). P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), performs its function by acetylating both histone and non-histone proteins. Our previous studies showed that PCAF was downregulated in HCC tissues and its high expression was significantly associated with patient survival after surgery, serving as a prognostic marker. In this study we found that overexpression of PCAF induced autophagy of HCC cells and its knockdown depressed autophagy. As type II programmed cell death, autophagy in...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: Original Article, Immunology, Cell Biology, Cancer Research, Cellular and Molecular Neuroscience, Molecular biology, Hepatocellular carcinoma, medicine.disease, medicine, PCAF, P300/CBP-Associated Factor, Biology, Autophagy, Cell, medicine.anatomical_structure
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publication . Article . 2018

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy.

Jia Yu-Li; Xu Meng; Dou Chang-Wei; Liu Zhi-Kui; Xue Yu-Mo; Yao Bo-Wen; Ding Ling-Long; Tu Kang-Sheng; Zheng Xin; Liu Qing-Guang;