publication . Other literature type . Article . 2009

Psychobiology and molecular genetics of resilience

Adriana Feder; Dennis S. Charney; Eric J. Nestler;
Open Access
  • Published: 01 Jun 2009
  • Publisher: Springer Science and Business Media LLC
Abstract
Every individual experiences stressful life events. In some cases acute or chronic stress leads to depression and other psychiatric disorders, but most people are resilient to such effects. Recent research has begun to identify the environmental, genetic, epigenetic and neural mechanisms that underlie resilience, and has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress.
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free text keywords: Article, General Neuroscience, Life events, Behavioral neuroscience, Biological neural network, Developmental psychology, Molecular genetics, medicine.medical_specialty, medicine, Psychological resilience, media_common.quotation_subject, media_common, Coping (psychology), Chronic stress, Psychology, Neuroscience, Adaptive change
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