publication . Conference object . Article . Other literature type . 2016

A novel chemo-mechano-biological model of arterial tissue growth and remodelling.

Pedro Aparicio; Paul Watton; Mark Thompson;
Open Access
  • Published: 01 Aug 2016 Journal: Journal of Biomechanics (issn: 0021-9290, Copyright policy)
  • Country: United Kingdom
Abstract
<p>Arterial growth and remodelling (GandR) is mediated by vascular cells in response to their chemical and mechanical environment. To date, mechanical and biochemical stimuli tend to be modelled separately, however this ignores their complex interplay. Here, we present a novel mathematical model of arterial chemo–mechano–biology. We illustrate its application to the development of an inflammatory aneurysm in the descending human aorta.</p> <p>The arterial wall is modelled as a bilayer cylindrical non–linear elastic membrane, which is internally pressurized and axially stretched. The medial degradation that accompanies aneurysm development is driven by an inflamm...
Subjects
free text keywords: Biophysics, Rehabilitation, Orthopedics and Sports Medicine, Biomedical Engineering, Mechanobiology, Remodelling, Collagen, Fibroblast, TGF-beta, Aneurysm, Mathematical model
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