publication . Conference object . Article . Other literature type . 2016

A novel chemo-mechano-biological model of arterial tissue growth and remodelling.

Pedro Aparicio; Paul Watton; Mark Thompson;
Open Access
  • Published: 01 Aug 2016 Journal: Journal of Biomechanics (issn: 0021-9290, Copyright policy)
  • Country: United Kingdom
<p>Arterial growth and remodelling (GandR) is mediated by vascular cells in response to their chemical and mechanical environment. To date, mechanical and biochemical stimuli tend to be modelled separately, however this ignores their complex interplay. Here, we present a novel mathematical model of arterial chemo–mechano–biology. We illustrate its application to the development of an inflammatory aneurysm in the descending human aorta.</p> <p>The arterial wall is modelled as a bilayer cylindrical non–linear elastic membrane, which is internally pressurized and axially stretched. The medial degradation that accompanies aneurysm development is driven by an inflamm...
free text keywords: Biophysics, Rehabilitation, Orthopedics and Sports Medicine, Biomedical Engineering, Mechanobiology, Remodelling, Collagen, Fibroblast, TGF-beta, Aneurysm, Mathematical model
49 references, page 1 of 4

Akhurst, R.J., Hata, A., 2012. Targeting the TGFβ signalling pathway in disease. Nat. Rev. Drug Discov. 11 (10), 790-811.

Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., Watson, J., 1994. Molecular Biology of the Cell, 3rd edition. Garland Publishing, New York, p. 984.

Aparicio, P., Mandaltsi, A., Boamah, J., Chen, H., Selimovic, A., Bratby, M., Uberoi, R., 2014. Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution. Int. J. Numer. Methods Biomed. Eng. 30, 563-586.

Baek, S., Rajagopal, K.R., Humphrey, J.D., 2006. A theoretical model of enlarging intracranial fusiform aneurysms. J. Biomed. Eng. 128, 142-149.

Baek, S., Valentin, A., Humphrey, J., 2007. Biomechanics of cerebral vasospasm and its resolution: II. Constitutive relations and model simulations. Ann. Biomed. Eng. 35 (9), 1498-1509.

Bai, Y., Lee, P.-F., Humphrey, J.D., Yeh, A.T., 2014. Sequential multimodal microscopic imaging and biaxial mechanical testing of living multicomponent tissue constructs. Ann. Biomed. Eng., 1-15.

Balakhovsky, K., Jabareen, M., Volokh, K., 2014. Modeling rupture of growing aneurysms. J. Biomech. 47 (3), 653-658.

Bellini, C., Ferruzzi, J., Roccabianca, S., Di Martino, E.S., Humphrey, J.D., 2014. A microstructurally motivated model of arterial wall mechanics with mechanobiological implications. Ann. Biomed. Eng. 42 (3), 488-502.

Brew, K., Dinakarpandian, D., Nagase, H., 2000. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim. Biophys. Acta 1477 (1-2), 267-283. [OpenAIRE]

Chen, H., 2014. Intracranial Aneurysm Disease: Novel Modelling of Inception and the Microstructural Adaption of Collagen Fabric (Ph.D. dissertation). University of Oxford.

Chiquet, M., Renedo, A.S., Huber, F., Flück, M., 2003. How do fibroblasts translate mechanical signals into changes in extracellular matrix production? Matrix Biol.: J. Int. Soc. Matrix Biol. 22 (1), 73-80.

Conway, D., Schwartz, M., 2012. Lessons from the endothelial junctional mechanosensory complex. F1000 Biol. Rep. 4 (January), 1.

Dai, J., Losy, F., Guinault, A.-M., Pages, C., Anegon, I., Desgranges, P., Becquemin, J.-P., Allaire, E., 2005. Overexpression of transforming growth factor-β1 stabilizes already-formed aortic aneurysms a first approach to induction of functional healing by endovascular gene therapy. Circulation 112 (7), 1008-1015.

Dai, J., Michineau, S., Franck, G., Desgranges, P., Becquemin, J.-P., Gervais, M., Allaire, E., 2011. Long term stabilization of expanding aortic aneurysms by a short course of cyclosporine a through transforming growth factor-beta induction. PloS One 6 (12), e28903.

Dale, P., Sherratt, J., Maini, P., 1996. A mathematical model for collagen fibre formation during foetal and adult dermal wound healing. Proc. R. Soc. London 263 (B), 653-660. [OpenAIRE]

49 references, page 1 of 4
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