publication . Other literature type . Article . 2004

Brain development during childhood and adolescence: a longitudinal MRI study

Jay N. Giedd; Jonathan Blumenthal; Neal O. Jeffries; F. X. Castellanos; Hong Liu; Alex Zijdenbos; Tomáš Paus; Alan C. Evans; Judith L. Rapoport;
  • Published: 17 Nov 2004
  • Publisher: Springer Science and Business Media LLC
Abstract
Pediatric neuroimaging studies1,2,3,4,5, up to now exclusively cross sectional, identify linear decreases in cortical gray matter and increases in white matter across ages 4 to 20. In this large-scale longitudinal pediatric neuroimaging study, we confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease. These changes in cortical gray matter were regionally specific, with developmental curves for the frontal and parietal lobe peaking at about age 12 and for the temporal lobe at about age 16, whereas cortical gray matter continued to increase in the o...
Subjects
free text keywords: Magnetic resonance imaging, medicine.diagnostic_test, medicine, Neuroscience, White matter, medicine.anatomical_structure, Occipital lobe, Gray (unit), Synaptic pruning, Cognitive psychology, Parietal lobe, Temporal lobe, Neuroimaging, Biology
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