publication . Article . Other literature type . 2014

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.

Sachet A. Shukla; Kristen E. Stevenson; Wandi Zhang; Stacey Gabriel; Carrie Sougnez; Vladimir Brusic; Jerome Ritz; Jerome Ritz; Gad Getz; Gad Getz; ...
Open Access
  • Published: 17 Jul 2014 Journal: Blood, volume 124, pages 453-462 (issn: 0006-4971, eissn: 1528-0020, Copyright policy)
  • Publisher: American Society of Hematology
Abstract
Genome sequencing has revealed a large number of shared and personal somatic mutations across human cancers. In principle, any genetic alteration affecting a protein-coding region has the potential to generate mutated peptides that are presented by surface HLA class I proteins that might be recognized by cytotoxic T cells. To test this possibility, we implemented a streamlined approach for the prediction and validation of such neoantigens derived from individual tumors and presented by patient-specific HLA alleles. We applied our computational pipeline to 91 chronic lymphocytic leukemias (CLLs) that underwent whole-exome sequencing (WES). We predicted ∼22 mutate...
Subjects
free text keywords: Immunology, Cell Biology, Biochemistry, Hematology, Transplantation, Chronic lymphocytic leukemia, medicine.disease, medicine, Human leukocyte antigen, Hematopoietic stem cell transplantation, medicine.medical_treatment, Leukemia, Cytotoxic T cell, Mutation, medicine.disease_cause, Antigen, Exome, Biology
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Europe PubMed Central
Other literature type . 2014
http://dx.doi.org/10.1182/bloo...
Other literature type . 2014
Provider: Datacite
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