publication . Other literature type . Article . 1999

How RNA folds.

Ignacio Tinoco; Carlos Bustamante;
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  • Published: 01 Oct 1999
  • Publisher: Elsevier BV
Abstract
We describe the RNA folding problem and contrast it with the much more difficult protein folding problem. RNA has four similar monomer units, whereas proteins have 20 very different residues. The folding of RNA is hierarchical in that secondary structure is much more stable than tertiary folding. In RNA the two levels of folding (secondary and tertiary) can be experimentally separated by the presence or absence of Mg2+. Secondary structure can be predicted successfully from experimental thermodynamic data on secondary structure elements: helices, loops, and bulges. Tertiary interactions can then be added without much distortion of the secondary structure. These ...
Subjects
free text keywords: Molecular Biology, Crystallography, Nucleic acid tertiary structure, RNA, Protein structure prediction, Protein tertiary structure, Protein folding, Protein secondary structure, Chemistry, Nucleic acid secondary structure, Contact order
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