publication . Article . Other literature type . 2001

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

Philipp von Hundelshausen; Weber, Ksc; Huo, Yq; Proudfoot, Aei; Nelson, Pj; Ley, K.; Weber, C.;
Open Access
  • Published: 03 Apr 2001
Background—Circulating platelets and chemoattractant proteins, such as the CC chemokine RANTES, contribute to the activation and interaction of monocytes and endothelium and may thereby play a pivotal role in the pathogenesis of inflammatory and atherosclerotic disease. Methods and Results—The binding of RANTES to human endothelial cells was detected by ELISA or immunofluorescence after perfusion with platelets or exposure to their supernatants. Monocyte arrest on endothelial monolayers or surface-adherent platelets was studied with a parallel-wall flow chamber and video microscopy. We show that RANTES secreted by thrombin-stimulated platelets is immobilized on ...
Medical Subject Headings: hemic and immune systems
free text keywords: Physiology (medical), Cardiology and Cardiovascular Medicine
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Other literature type . 2001
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Article . 2001
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