publication . Other literature type . Article . 2008

What is the mammalian dentate gyrus good for?

A. Treves; A. Tashiro; M.P. Witter; E.I. Moser;
  • Published: 01 Jul 2008
  • Publisher: Elsevier BV
Abstract
Abstract In the mammalian hippocampus, the dentate gyrus (DG) is characterized by sparse and powerful unidirectional projections to CA3 pyramidal cells, the so-called mossy fibers (MF). The MF form a distinct type of synapses, rich in zinc, that appear to duplicate, in terms of the information they convey, what CA3 cells already receive from entorhinal cortex layer II cells, which project both to the DG and to CA3. Computational models have hypothesized that the function of the MF is to enforce a new, well-separated pattern of activity onto CA3 cells, to represent a new memory, prevailing over the interference produced by the traces of older memories already sto...
Subjects
free text keywords: General Neuroscience, Biology, Neurophysiology, Synapse, Dentate gyrus, Entorhinal cortex, Memoria, Neuroscience, Central nervous system, medicine.anatomical_structure, medicine, Hippocampus, Neurogenesis
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publication . Other literature type . Article . 2008

What is the mammalian dentate gyrus good for?

A. Treves; A. Tashiro; M.P. Witter; E.I. Moser;