publication . Other literature type . Article . 2011

The role of ubiquitylation in immune defence and pathogen evasion

Jiang, Xiaomo; Chen, Zhijian J.;
  • Published: 09 Dec 2011
  • Publisher: Springer Science and Business Media LLC
Abstract
Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. Recent studies have revealed crucial roles of ubiquitylation in many aspects of the immune system, including innate and adaptive immunity and antimicrobial autophagy. In addition, mounting evidence indicates that microbial pathogens exploit the ubiquitin pathway to evade the host immune system. Here, we r...
Subjects
Medical Subject Headings: biochemical phenomena, metabolism, and nutritionbacteria
free text keywords: Immunology, Biology, Pathogen, Ubiquitin, biology.protein, Innate immune system, Acquired immune system, Signal transduction, Antigen presentation, Immune system, Cell biology, Immune defence, Article
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