publication . Article . Other literature type . 2008

Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

Jenny Clarkson; Xavier d'Anglemont de Tassigny; Adriana Santos Moreno; William H Colledge; Allan E Herbison;
Open Access
  • Published: 27 Aug 2008 Journal: Journal of Neuroscience, volume 28, pages 8,691-8,697 (issn: 0270-6474, eissn: 1529-2401, Copyright policy)
  • Publisher: Society for Neuroscience
Abstract
Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans. The gonadotropin-releasing hormone (GnRH) neurons represent the final output neurons of the neural network controlling fertility and are suspected to be the primary locus of kisspeptin–GPR54 signaling. Using mouse models, the present study addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation. Dual-label immunocytochemistry experiments showed that 40–60% of kisspeptin neurons in the rostral periventricula...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonistsnervous systemendocrine system
free text keywords: General Neuroscience, Biology, Luteinizing hormone, Internal medicine, medicine.medical_specialty, medicine, Kisspeptin, Endocrinology, Neuron, medicine.anatomical_structure, Gonadotropin-releasing hormone, GnRH Neuron, Gonadotropin, medicine.drug_class, Estrogen receptor, Anteroventral periventricular nucleus, Articles
Abstract
Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans. The gonadotropin-releasing hormone (GnRH) neurons represent the final output neurons of the neural network controlling fertility and are suspected to be the primary locus of kisspeptin–GPR54 signaling. Using mouse models, the present study addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation. Dual-label immunocytochemistry experiments showed that 40–60% of kisspeptin neurons in the rostral periventricula...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonistsnervous systemendocrine system
free text keywords: General Neuroscience, Biology, Luteinizing hormone, Internal medicine, medicine.medical_specialty, medicine, Kisspeptin, Endocrinology, Neuron, medicine.anatomical_structure, Gonadotropin-releasing hormone, GnRH Neuron, Gonadotropin, medicine.drug_class, Estrogen receptor, Anteroventral periventricular nucleus, Articles
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publication . Article . Other literature type . 2008

Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

Jenny Clarkson; Xavier d'Anglemont de Tassigny; Adriana Santos Moreno; William H Colledge; Allan E Herbison;