publication . Other literature type . Article . 2010

Granger causality relationships between local field potentials in an animal model of temporal lobe epilepsy.

William Ditto; Thomas Mareci;
Open Access English
  • Published: 19 Mar 2010
Abstract
An understanding of the in vivo spatial emergence of abnormal brain activity during spontaneous seizure onset is critical to future early seizure detection and closed-loop seizure prevention therapies. In this study, we use Granger causality (GC) to determine the strength and direction of relationships between local field potentials (LFPs) recorded from bilateral microelectrode arrays in an intermittent spontaneous seizure model of chronic temporal lobe epilepsy before, during, and after Racine grade partial onset generalized seizures. Our results indicate distinct patterns of directional GC relationships within the hippocampus, specifically from the CA1 subfiel...
Subjects
free text keywords: Article, General Neuroscience
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